[Combination of toxic multinodular goiter and primary hyperparathyroidism with rare ectopia of parathyroma].

A well-known feature of primary hyperparathyroidism (PHPT) is possible ectopic localization of parathyroid adenoma that can significantly complicate diagnostic process. Ectopia in the aortic window is extremely rare and accounts only 1% of ectopic parathyroid adenomas in the mediastinum and 0.24% among all parathyroid adenomas.

[Current approach to the diagnosis and treatment of primary hyperparathyroidism].

Aim: To optimize diagnosis and surgical treatment of patients with primary hyperparathyroidism.

Material And Methods: Retrospective comparative analysis of diagnosis and surgical treatment included 444 patients who were treated at the specialized department of endocrine surgery of Pirogov National Medical Surgical Center in 2012-2017. Archival materials and electronic databases of the clinic were applied.

Risk factors and prognosis of voice disorders after surgical treatment of thyroid and parathyroid diseases.

Aim: To analyze risk factors and prognosis of voice disorders after surgical treatment of thyroid and parathyroid diseases.

Material And Methods: There were 1272 patients who were operated in the endocrine surgery department for the period from January 1, 2016 to April 30, 2017. We studied the incidence of VF paresis, VF paralysis, and persistent dysphonia as clinical outcomes.

[Experience of hyperbaric oxygenation treatment of a patrient with acute hypobaropathy].

Five sessions of computerized hyperbaric oxygenation treatment resulted in complete recovery of a patient with acute hypobaropathy developed after a 4-day ascent onto m. Kailas (4800 m) in the Tibet.

[Nanobiotechnology and nanomedicine].

Nanobiotechnology is a new direction in the technological science, which plays a key role in creation of nanodevices for analysis of living systems on a molecular level. Nanomedicine is the application of nanotechnologies in medicine for maintenance and improvement of human life using the knowledge on human organism at a molecular level. Application of nanoparticles and nanomaterials for the diagnostic and therapeutic purposes is now significantly extended in nanomedicine.

[Role of the hydrophobicity of polymethylene-bis-quaternary ammonium compounds in the mechanism of their curare-like action].

Lengthening of the N-alkyl radical (from--C2H5 to C10H21) in the series of polymethylene-bis-quaternary ammonium compounds was found to result in an increased hydrophobic properties of the compounds. In the presence of the N-butyl radical the mode of the action exerted by the substances changes, viz. from depolarizing they turn into antidepolarizing ones.

[Role of the hydrophobicity of monoquaternary ammonium compounds in the mechanism of their curariform action].

The lengthening of the alkyl radical at the quaternary nitrogen atom (from -C2H5 to -C20H41) in the series of alkyltrimethylammonium compounds was found to lead to a gradually growing hydrophobicity of the compound. A change in the mechanism responsible for the myoparalytic action of the compound is due to a mounting degree of hydrophobicity. With the methyl group in the molecule of tetramethylammonium replaced with polyalicyclic radicals (bornyl, adamantyl) the compound, acting after a non-depolarizing type, possess a greater degree of hyrophobicity than do substances of the depolarizing type.