Comparing Conventional Physician-Led Education with VR Education for Pacemaker Implantation: A Randomized Study.

Introduction: Education of patients prior to an invasive procedure is pivotal for good cooperation and knowledge retention. Virtual reality (VR) is a fast-developing technology that helps educate both medical professionals and patients.

Objective: To prove non-inferiority of VR education compared to conventional education in patients prior to the implantation of a permanent pacemaker (PPM).

Code4ML: a large-scale dataset of annotated Machine Learning code.

The use of program code as a data source is increasingly expanding among data scientists. The purpose of the usage varies from the semantic classification of code to the automatic generation of programs. However, the machine learning model application is somewhat limited without annotating the code snippets.

Virioplankton and virus-induced mortality of prokaryotes in the Kara Sea (Arctic) in summer.

Among the Arctic seas, the largest volume of river runoff (~45% of the total river-water inflow into the Arctic Ocean) enters the Siberian Kara Sea. The viral communities of the Kara Sea are important for the functioning of the marine ecosystem. Studies of virus-prokaryote interactions on the Kara Sea shelf have been conducted only in spring and autumn.

Production of Fluorescent Dissolved Organic Matter by Microalgae Strains from the Ob and Yenisei Gulfs (Siberia).

Dissolved organic matter (DOM) is an important component of aquatic environments; it plays a key role in the biogeochemical cycles of many chemical elements. Using excitation-emission matrix fluorescence spectroscopy, we examined the fluorescent fraction of DOM (FDOM) produced at the stationary phase of growth of five strains of microalgae sampled and isolated from the Ob and Yenisei gulfs. Based on the morphological and molecular descriptions, the strains were identified as diatoms (, cf.

Drug Use Homophily in Adolescent Offenders' Close Friendship Groups.

Adolescents who befriend drug using peers may be at risk for initiated and continued substance use. The present secondary data analysis examined how drug use homophily (i.e.

Adolescents' adherence to Centers for Disease Control and Prevention guidelines during the COVID-19 pandemic.

Background: The outbreak of the coronavirus (COVID-19) pandemic in the United States resulted in safety guidelines from the Centers for Disease Control and Prevention (CDC) intended to curb the spread of the virus. Adolescents are potentially at risk for disregarding these guidelines due to their reduced psychosocial maturity compared with adults. The current study examined the relationship between adolescents' psychosocial maturity, perceived importance of the CDC guidelines and adherence to the CDC guidelines within some of the highest risk groups for contracting COVID-19 in a county particularly impacted by the pandemic (i.

Effect of blue and red monochromatic light during incubation on the early post-embryonic development of immune responses in broiler chicken.

1. The light regime during incubation can influence embryonic and post-embryonic life and its effects can be mediated by rhythmic melatonin production in the embryonic pineal gland.2.

MARKETING AUDIT OF UKRAINIAN PHARMACEUTICAL MARKET FOR LOCAL TREATMENT ACNE AND DEMODICOSIS.

Objective: The aim: To conduct a marketing audit of the pharmaceutical market of Ukraine for acne and demodicosis medications.

Patients And Methods: Materials and methods: The study used marketing methods of analysis, survey, observation methods and reference literature - State Register of Medicines of Ukraine of the State Expert Center of the Ministry of Health of Ukraine.

Results: Results: As a result of marketing audit of retail audit data of pharmacy sales revealed that the leading sales in packaging is MNL benzylbenzoate, the share of which reached in different years from 45% to 32%, which was 1380902 and 647576 packages per year, respectively, in second place - metronidazole , benzoyl peroxide, zinc ointment and sulfur ointment respectively.

Dataset on optical characteristics and spectroscopic indices of dissolved organic matter of the Kara, Laptev, and East Siberian seas in August-September 2017.

A total of 137 water samples to study optical properties of chromophoric dissolved organic matter were collected in the Artic shelf seas during the 69th cruise on board the R/V in August-September 2017. Sampling sites were located in the Kara, Laptev and East Siberian seas and associated to the areas influenced by terrestrial runoff of the Kolyma, Indigirka, Lena, Khatanga, Ob and Yenisei rivers. In this data article, conventional spectroscopic indices and lignin phenol concentrations, calculated on the basis of fluorescence and UV-vis absorption spectra, are presented.

Development and reactivity of the immune system of Japanese quail lines divergently selected for the shape of the growth curve.

1. Selection strategies for broilers must balance rapid growth with the welfare and health of animals, strategies must deal with the trade-off with other vital functions.2.

Healthcare-associated infections in intensive care units.

Objective: Introduction: Healthcare-associated infections (HAIs) remain a major public health problem and patient safety threat worldwide. Scant information is available on the occurrence HAI and antimicrobial susceptibility of responsible pathogens in Ukrainian intencive care units (ICUs). The aim: To evaluate the prevalence of HAIs and antimicrobial resistance of the responsible pathogens.

Prevalence of healthcare-associated infections and antimicrobial resistance in acute care hospitals in Kyiv, Ukraine.

Background: Healthcare-associated infections (HAIs) are among the most common adverse events in patient care, and account for substantial morbidity and mortality.

Aim: To obtain the first estimates of the current prevalence of HAIs and antimicrobial resistance in acute care hospitals in Kyiv, Ukraine.

Methods: Prospective surveillance was conducted from January 2014 to December 2016 in five acute care hospitals in Kyiv.

The effect of different wavelengths of light during incubation on the development of rhythmic pineal melatonin biosynthesis in chick embryos.

Rhythmic pineal melatonin biosynthesis develops in chick embryos incubated under a light (L)-dark (D) cycle of polychromatic white light. The spectral sensitivity of the embryonic pineal gland is not known and was investigated in this study. Broiler breeder eggs (Ross 308, n=450) were incubated under white, red, green or blue light under the 12L : 12D cycle.

Clinical validation of the "7 × 7" questionnaire for patients with functional gastrointestinal disorders.

Background And Aim: Physicians use different scales and questionnaires to assess the severity of clinical symptoms in patients with functional gastrointestinal disorders. The current study aimed to validate the "7 × 7" questionnaire for assessment of severity of the symptoms as a tool for the efficacy of treatment of functional gastrointestinal disorders, using the Clinical Global Impressions scale as the reference standard.

Methods: Fifty inpatients aged from 18 to 64 with a confirmed diagnosis of irritable bowel syndrome (26 patients, 52%), functional dyspepsia (15 patients, 30%), or both (9 patients, 18%) were prospectively enrolled in the study.

A new look at acid catalyzed deacetylation of carbohydrates: A regioselective synthesis and reactivity of 2-O-acetyl aryl glycopyranosides.

In the present work we report that acetyl groups of per - acetylated aryl glycosides have different reactivity during the acidic deacetylation using HCl/EtOH in CHCl which leads to preferential deacetylation at O-3, O-4 and O-6. Thereby, the one-step preparation of 2-O-acetyl aryl glycosides with simple aglycon was accomplished for the first time. It was proved that the found reagent is to be general and unique for the preparation of series of 2-О-acetyl aryl glycosides.

Analytical calculation of the lipid bilayer bending modulus.

Bending and Gaussian moduli of a homogenious single-component lipid bilayer are calculated analytically using microscopic model of the lipid hydrocarbon chains. The approach allows for thermodynamic averaging over different chains conformations. Each chain is modeled as a flexible string with finite bending rigidity and an incompressible cross-section area.

The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease.

Aim: The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD.

Methods: From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database.

Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients.

Background: Treadmill exercise nitrogen-13 ((13)N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients.

Methods And Results: Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study.

The impact of dementia development concurrent with Parkinson's disease: a new perspective.

Dementia is the leading cause of disability worldwide among chronic diseases in the elderly and is a major contributor to mortality. Importantly, dementia that develops as a comorbid condition significantly compounds the burden of disease on the person, their caregivers and the health care system. Dementia is a frequent comorbidity of Parkinson's disease (PD) and about 80% of people with PD will develop dementia during the course of the disease.

Sleep apnea prevalence in acute myocardial infarction--the Sleep Apnea in Post-acute Myocardial Infarction Patients (SAPAMI) Study.

Background: While sleep apnea (SA) might be a modifiable cardiovascular risk factor, recent data suggest that SA is severely underdiagnosed in patients after acute myocardial infarction (MI). There is limited evidence about day-night variation of onset of MI on dependence of having SA. We therefore investigated the prevalence of SA and examined the day-night variation of onset of MI in acute MI patients.

Prognostic value of stress-only and stress-rest normal gated SPECT imaging: higher incidence of cardiac hard events in diabetic patients who underwent full stress-rest imaging.

Background: The European procedural guidelines for cardiac gated SPECT imaging demonstrate considerable variability in recommended administered radiopharmaceutical activity and imaging protocols. This study compared stress-only and stress-rest protocols to evaluate the safety of stress-only imaging, and to identify characteristics of patients who need full stress-rest imaging.

Methods: Patients referred for a chest pain were scheduled for stress-rest gated SPECT imaging.

Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment.

The importance of glycans in biological systems is highlighted by their various functions in physiological and pathological processes. Many glycan epitopes on glycoproteins and glycolipids are based on N-acetyllactosamine units (LacNAc; Galβ1,4GlcNAc) and often present on extended poly-LacNAc glycans ([Galβ1,4GlcNAc](n)). Poly-LacNAc itself has been identified as a binding motif of galectins, an important class of lectins with functions in immune response and tumorigenesis.

[Analysis of results of excerpts of generalized parametric indicators of facet classification of occupations in medicine, practical, industrial pharmacy, cosmetology and major of related occupations introduced to State classifiers 003:2010].

A comparative analysis of the content and the list of codified occupations (CO) of State classifiers (SC) of occupations SC 003-95 and SC 003:2010 (total 15 000 positions) is considered. Found that the number of corresponding CO in the SC 003-95 consist of 906 items including 57 of Vol. 78 "Care of public health", as well as in SC 003:2010 - 799 and 59 respectively.

Reduced content of α-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease.

Measurement of α-synuclein level in the peripheral blood was proposed as a diagnostic test for Parkinson's disease. However, the results of these studies remain contradictory, probably because the examined samples included patients with different etiology of Parkinson's disease. To verify this assumption we studied the levels of α-synuclein in peripheral blood leukocytes of patients with Parkinson's disease associated with mutations in the gene of leucine-rich kinase 2 (LRRK2).

Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors.

This work reveals new structural relationships in the complex process of the interaction between activation receptors of natural killer cells (rat NKR-P1, human CD69) and novel bivalent carbohydrate glycomimetics. The length, glycosylation pattern and linker structure of receptor ligands were examined with respect to their ability to precipitate the receptor protein from solution, which simulates the in vivo process of receptor aggregation during NK cell activation. It was found that di-LacdiNAc triazole compounds show optimal performance, reaching up to 100% precipitation of the present protein receptors, and achieving high immunostimulatory activities without any tendency to trigger activation-induced apoptosis.