Prevalence of LDL-hypercholesterolemia and other cardiovascular risk factors in young people with type 1 diabetes.

Background: Mortality and morbidity in people with Type 1 diabetes (T1D) is mainly caused by cardiovascular disease (CVD). Early treatment of cardiovascular risk factors (CVRFs) is of great importance.

Objective: To analyze the prevalence of LDL-hypercholesterolemia and other CVRFs in youth with T1D.

Cerebral impact of prenatal irradiation by 131I: an experimental model of clinical neuroradioembryological effects.

Unlabelled: Human brain in prenatal period is a most vulnerable to ionizing radiation body structure. Unlike atomic bombings or radiological interventions in healthcare leading at most to external irradiation the intensive internal exposure may occur upon nuclear reactor accidents followed by substantial release and fallout of radioactive 131I. The latter can lead to specific neuroradioembryological effects.

Geno- and cytotoxic effects in bone marrow cells and peripheral blood induced by the prolonged administration of 131I to the laboratory rats.

Objective: to evaluate the state of to assess the state of hematopoietic system of experimental rats according to the geno and cytotoxic effects in bone marrow and changes in morphology composition of peripheral blood caused by prolonged 131I intake.

Materials And Methods: Within 15 days sodium iodide with activity of 29,3 kBq/animal was daily orally administered to Wistar rats. At 1, 2, 3, 7 and 15 days specific radioisotope activity, level of micronuclei in bone marrow cells, cyto toxicity index, number of erythrocytes and leucocytes in peripheral blood were determined.

[Application of mini-invasive methods of elimination of horizontal reflux in patients with varicose disease of the lower extremities complicated by active trophic ulcers].

The results of surgical treatment of 153 patients for varicose disease of the lower extremities, complicated by trophic ulcers of the feet, were summarized. Miniinvasive methods were applied in patients of the main group for elimination of horizontal reflux, causing the increase of the favorable (excellent and good) results of treatment rate by 36.22% and the reduction of unfavorable results rate--by 15.

[Frequency of drug resistant tuberculosis in Poland in 2000 as compared to 1997].

Prevalence of drug resistance to one drug and multidrug resistance--MDR in different categories of tuberculosis patients is an important information about the susceptibility pattern of Mycobacterium tuberculosis isolates against antimycobacterial drugs. Poland joined WHO/IUATLD global project on TB drug resistance surveillance, and carried out in 1996/1997 the first prospective survey, simultaneously on primary and acquired drug resistance. This study is repeated in 2000 according to the WHO/IUATLD protocol.

[A micronucleus analysis of the peripheral blood lymphocytes of the professional contingent and of the self-settlers in the exclusion zone of the Chernobyl Atomic Electric Power Station].

The chromosomal damage (micronuclei) of the peripheral blood lymphocytes of the group of professionals who had participated in the liquidation of the Chernobyl NPP accident and have continued their work at the "Shelter" and of the group of self-settlers who living for about ten year in the Chernobyl NPP alienation zone were studied. Residents of Kyïv were the group for comparison. It was found that in professionals the number of micronuclei was higher due to the presence of cells with several micronuclei while in the self-settlers it was due to the increase in the number of cells with one micronucleus.

[Increase of life span in mice under acute cooling and effects ofa preparation isolated from Laminaria saccharina].

Efforts against cold is a significant problem during work in the Arctic. In experiments on grey mice it was demonstrated that drugs from Laminaria Saccarina increase life time of animals in cold temperature (-18 degrees C) by 61%.

[Condition of cell membranes in simulated motion sickness and use of alpha-tocopherol].

The purpose of the work was to study the mechanism responsible for adaptive reorganization of membranes--lipid peroxidation during simulated motion sickness (MS) in animals. It was shown that during MS rats exhibited an elevation of the level of diene conjugates and Schiff foundations in the brain indicating lipid peroxidation activation. A similar increase of phospholipase A2 activity in the brain was noted.

[Effects of peptide-protein substances from the hydrobiontics in vestibulo-autonomic disorders in cats].

We demonstrated earlier, that undecapeptide of hydra vulgaris possesses vestibulo-protective activities in cats. We also investigated potential of vestibulo-protective properties of other peptide-protein substances from hydrobiontics. The work was done on 18 cats.

[Comparative influence of nootropic preparations on the emetic effect of morphine].

The effect of electroshock (ECS) and piracetam, oxiracetam or N-acetylglycinamide on the passive avoidance conditioned response in rats was studied. The antiemetic effect of the compounds was examined in cats as well. The results obtained allowed us to distinct the nootropic and antiemetic action of the drugs.

[Vestibulo-protective properties of regulatory peptides].

Endogenous opioid peptides take an active part in the pathogenesis of motion sickness (MS). Some regulatory peptides (substances P, gamma and des-tyr-gamma-endorphins) manifest antiemetic properties, unlike opioid peptides and morphine. Thus, we have examined the vestibulo-protective properties of some regulatory peptides during simulation of MS in cats.

[Influence of piracetam on the effects of narcotic analgesics and opioid peptides].

Piracetam possesses some properties not related to the nootropic activity. The purpose of the work was to study piracetam influence on effects of narcotic analgesics and opioid peptides at intracerebroventricular administration. In experiments on cats it was found that piracetam in a dose-dependent way prevented the emetic effect of morphine and leu-enkephalin.

[Neuropharmacology of the autonomic vestibular syndrome].

It was found during studies on man and experiments on animals that various neuromediator systems of the organism (M-cholinergic, H1-histaminergic, dopaminergic, and opioidergic) are involved in the genesis of VVS. In addition, animal experiments showed that of great importance in the process are different regulatory peptides, in particular, substance P and beta-endorphin. The findings indicate that some neuropeptides may be used in the future in man for VVS prevention.

[Role of opioid peptides in the pathogenesis of vestibulo-autonomic disorders].

The study was carried out using 12 noninbred male cats and 14 white rats. In response to vestibulo-autonomic disorders the rats showed a decrease of beta-endorphin in the midbrain, medulla oblongata and hypothalamus as well as a reduction of met-enkephalin in the hypothalamus and medulla oblongata. The concentration of met-enkephalin in the adrenals increased and that of beta-endorphin in blood did not change.

[Functioning of the pituitary-adrenal system during the vestibulo-vegetative syndrome and administration of dalargin and nalorphine].

Changes in ACTH, cortisol, beta-endorphin have been investigated during vestibulo-vegetative syndrome (VVS) and injections of dalargin (leu-enkephalin analog) and nalorphine (agonist-antagonist of opioid receptors) in 9 volunteers with low level vestibulo-vegetative stability. Cumulative coriolis acceleration test during rotations on a special chair was used for VVS modelling. Dalargin (1-4 mg), nalorphine (5 mg) and placebo (NaCl solution) were injected intravenously 5-15 min before rotation.

[Emetic and antiemetic properties of regulatory peptides].

Emetic and antiemetic properties of opioid peptides, substance "P", beta-lipotropin, and ACTH1-39 have been investigated in experiments on cats. It was shown that morphine, enkephalin, beta-endorphin and DADLE caused vomiting in animals, which was blocked by naloxone. Substance "P", gamma- and des-tyr-gamma-endorphin manifested antiemetic properties similar to those of naloxone.