Precise Large-Scale Chemical Transformations on Surfaces: Deep Learning Meets Scanning Probe Microscopy with Interpretability.

Scanning probe microscopy (SPM) techniques have shown great potential in fabricating nanoscale structures endowed with exotic quantum properties achieved through various manipulations of atoms and molecules. However, precise control requires extensive domain knowledge, which is not necessarily transferable to new systems and cannot be readily extended to large-scale operations. Therefore, efficient and autonomous SPM techniques are needed to learn optimal strategies for new systems, in particular for the challenge of controlling chemical reactions and hence offering a route to precise atomic and molecular construction.

Clarifying terminology and definitions in education services for mental health users: A disambiguation study.

In the wake of the mental health crisis in children and adolescents, the coordination of education and mental health services has become a global priority. However, differing terminologies and classifications across sectors, hinder effective comparison. The classification in education focuses mainly on outputs like qualifications or throughputs like teaching programs.

Clinical effectiveness, cost-effectiveness and process evaluation of group schema therapy for eating disorders: study protocol for a multicenter randomized controlled trial.

Background: Eating disorders (EDs), such as (atypical) Anorexia (AN) and Bulimia Nervosa (BN), are difficult to treat, causing socioeconomic impediments. Although enhanced cognitive behavioral therapy (CBT-E) is widely considered clinically effective, it may not be the most beneficial treatment for (atypical) AN and BN patients who do not show a rapid response after the first 4 weeks (8 sessions) of a CBT-E treatment. Alternatively, group schema therapy (GST) may be a valuable treatment for this ED population.

Microwave excitation of atomic scale superconducting bound states.

Magnetic impurities on superconductors lead to bound states within the superconducting gap, so called Yu-Shiba-Rusinov (YSR) states. They are parity protected, which enhances their lifetime, but makes it more difficult to excite them. Here, we realize the excitation of YSR states by microwaves facilitated by the tunnel coupling to another superconducting electrode in a scanning tunneling microscope (STM).

Electric control of spin transitions at the atomic scale.

Electric control of spins has been a longstanding goal in the field of solid state physics due to the potential for increased efficiency in information processing. This efficiency can be optimized by transferring spintronics to the atomic scale. We present electric control of spin resonance transitions in single TiH molecules by employing electron spin resonance scanning tunneling microscopy (ESR-STM).

Real-Space Imaging of Triplon Excitations in Engineered Quantum Magnets.

Quantum magnets provide a powerful platform to explore complex quantum many-body phenomena. One example is triplon excitations, exotic many-body modes emerging from propagating singlet-triplet transitions. We engineer a minimal quantum magnet from organic molecules and demonstrate the emergence of dispersive triplon modes in one- and two-dimensional assemblies probed with scanning tunneling microscopy and spectroscopy.

Measurement system for ultraviolet channel modeling and communications.

There has been an increasing interest in ultraviolet (UV) communications as a promising technology for non-line-of-sight (NLOS) networking by exploiting atmospheric scattering at UV wavelengths that enables a unique NLOS UV communication channel. While there has been significant theoretical and simulation-based investigation of the UV channel characteristics, there is limited work in terms of experimental research and validation of the analytical models. In this paper, we present a flexible experimental system for precise UV channel and communications measurements.

Methods for think-aloud interviews in health-related resource-use research: the PECUNIA RUM instrument.

Background: The think-aloud (TA) approach is a qualitative research method that allows for gaining insight into thoughts and cognitive processes. It can be used to incorporate a respondent's perspective when developing resource-use measurement (RUM) instruments. Currently, the application of TA methods in RUM research is limited, and so is the guidance on how to use them.

Challenging Future Generations: A Qualitative Study of Students' Attitudes toward the Transition to Animal-Free Innovations in Education and Research.

In 2016, the Dutch government declared its commitment to phasing out animal experiments by 2025. Although a high number of animal experiments are still performed and the 2025 target will not be met, the commitment remains. Efforts are being made to identify levers that might foster the transition to animal-free science.

Development of an Instrument for the Assessment of Health-Related Multi-sectoral Resource Use in Europe: The PECUNIA RUM.

Background: Measuring objective resource-use quantities is important for generating valid cost estimates in economic evaluations. In the absence of acknowledged guidelines, measurement methods are often chosen based on practicality rather than methodological evidence. Furthermore, few resource-use measurement (RUM) instruments focus on the measurement of resource use in multiple societal sectors and their development process is rarely described.

International comparability of reference unit costs of education services: when harmonizing methodology is not enough (PECUNIA project).

Background: Health problems can lead to costs in the education sector. However, these costs are rarely incorporated in health economic evaluations due to the lack of reference unit costs (RUCs), cost per unit of service, of education services and of validated methods to obtain them. In this study, a standardized unit cost calculation tool developed in the PECUNIA project, the PECUNIA RUC Template for services, was applied to calculate the RUCs of selected education services in five European countries.

Optimization of ultraviolet communication links based on finite difference stochastic approximation.

The ultraviolet communication (UV) channel has been shown to have unique features that could be exploited for covert ground-to-ground communications in complex non-line-of-sight (NLOS) scenarios. A key challenge is the determination of optimal configuration of pointing directions of the UV nodes in unknown NLOS environments to maximize the link performance. In this paper, we proposed a novel steering optimization approach based on Finite Difference Stochastic Approximation (FDSA) to simultaneously optimize the transmitter (Tx) and receiver (Rx) pointing directions without any knowledge about the locations and relative orientations of the two nodes.

Associations between muscle mass/strength and healthcare costs/use for patients with cancer: A systematic literature review.

Purpose: To review published scientific evidence evaluating the potential associations between muscle mass/strength and healthcare use/costs for patients with cancer.

Methods: In accordance with the predefined protocol for a systematic literature review, studies assessing potential associations between muscle mass/strength and healthcare costs/use in cancer patients were searched on MEDLINE (via Ovid) and on the NHS Economic Evaluation Database in September 2021. Study selection, data extraction and quality assessment were performed by two independent reviewers.

Combining electron spin resonance spectroscopy with scanning tunneling microscopy at high magnetic fields.

The continuous increase in storage densities and the desire for quantum memories and computers push the limits of magnetic characterization techniques. Ultimately, a tool that is capable of coherently manipulating and detecting individual quantum spins is needed. Scanning tunneling microscopy (STM) is the only technique that unites the prerequisites of high spatial and energy resolution, low temperature, and high magnetic fields to achieve this goal.

Facilitators and barriers for the implementation of resuscitation training programmes for schoolchildren: A systematic review.

Background: Training schoolchildren in resuscitation seems to improve rates of resuscitation by bystanders. Leading medical societies recommend comprehensive resuscitation education in schools. To date, no widespread implementation within the European Union has happened.

Aspects and Challenges of Resource Use Measurement in Health Economics: Towards a Comprehensive Measurement Framework.

Background: While the methods for conducting health economics research in general are improving, current guidelines provide limited guidance regarding resource use measurement (RUM). Consequently, a variety of methods exists, yet there is no overview of aspects to consider when deciding on the most appropriate RUM methodology. Therefore, this study aims to (1) identify and categorize existing knowledge regarding aspects of RUM, and (2) develop a framework that provides a comprehensive overview of methodological aspects regarding RUM.

Do Costs in the Education Sector Matter? A Systematic Literature Review of the Economic Impact of Psychosocial Problems on the Education Sector.

Background: Psychosocial (e.g., anxiety or behavior) problems lead to costs not only in the healthcare sector but also in education and other sectors.

Economic Impact of the Introduction of Outpatient Medical Specialist Care (ASV) of Gastrointestinal Cancer Patients from a German Hospital Management Perspective.

Introduction: The treatment of cancer patients in Germany is characterized by sectoral separation of the in- and outpatient care accompanied by 2 separate reimbursement systems. By introducing the Guideline of Outpatient Medical Specialist Care in accordance with §116b SGB V (ASV) in 2014, the German legislation empowers office-based physicians and hospitals to jointly provide medical care in the ambulatory setting.

Methods: A 1-year period each before and after the introduction of ASV was compared by means of data from the Center for Integrated Oncology Cologne at the University Hospital of Cologne.

Regional Cerebral Associations Between Psychometric Tests and Imaging Biomarkers in Alzheimer's Disease.

Recently, imaging biomarkers have gained importance for the characterization of patients with Alzheimer's disease; however, the relationship between regional biomarker expression and cognitive function remains unclear. In our study, we investigated associations between scores on CERAD neuropsychological assessment battery (CERAD-NAB) subtests with regional glucose metabolism, cortical thickness and amyloid deposition in patients with early Alzheimer's disease (AD) using [18F]-fluorodeoxyglucose (FDG), structural MRI, and 11C-Pittsburgh Compound B (PiB) positron emission tomography (PET), respectively. A total of 76 patients (mean age 68.

Analysis of the low-probability-of-detection characteristics of ultraviolet communications.

Deep ultraviolet wavelengths have been proposed for low-probability-of-detection (LPD) communications, particularly for non-line-of-sight (NLOS) links, because of the increased atmospheric absorption at these wavelengths. Motivated by this favorable feature, we develop a modeling framework to quantitatively study the LPD characteristics of ultraviolet communications (UVC). We then demonstrate the application of our modeling framework by considering various friendly and adversarial system configurations and quantifying the proposed LPD metric (the range at which an adversary can detect communications that uses the minimum power needed to meet given communications performance requirements), as well as investigating the sensitivity of the analysis to various scenario parameters.

Exploring the identification, validation, and categorization of the cost and benefits of criminal justice in mental health: the PECUNIA project.

Background: Mental health disorders and their treatments produce significant costs and benefits in both healthcare and non-healthcare sectors. The latter are often referred to as intersectoral costs and benefits (ICBs). Little is known about healthcare-related ICBs in the criminal justice sector and how to include these in health economics research.

Identifying predictive factors for vertebral collapse fractures in multiple myeloma patients.

Background Context: Vertebral compression fractures (VCFs) are a common complication for patients with multiple myeloma. These fractures are associated with significant morbidity and mortality due to severe back pain, spinal instability, increased risk of new fractures, neurologic dysfunction, and other physical symptoms.

Purpose: To identify risk factors associated with the development of VCFs which may help to predict them in future patients.