Cerebroprotective properties of recombinant interleukin-1 receptor - an experimental study.

Optimization of therapy of cerebrovascular disorders (CVD) is one of the most critical health problems. The current treatment regimen of CVD turns out to be often insufficient. Search for new drugs with cerebroprotective and antihypoxic properties is an essential task of modern medicine and pharmacy.

Experience and prospects for the use of off-label drugs in oncology.

According to the World Health Organization, half of all drugs available on the global pharmaceutical market are sometimes used for indications that are not included in the instruction for use. This method of therapy has the term "off-label use" which means the use "out of instruction". Today, off-label drugs are also prescribed for cancer treatment.

[The mechanism of the pulmoprotective action of carboxytherapy].

The problem of finding new ways for pharmacological prophylaxis and treatment of respiratory tract diseases is very relevant in public health. To eliminate hypoxia, many European and American clinics use carboxytherapy as an additional or alternative treatment. Carbon dioxide administration eliminates the sequels of oxygen starvation, by producing artificial tissue hypercapnia, which causes an increase in oxygen delivery and carbon dioxide removal from the tissues and then from the body.

[Carboxytherapy - an innovative trend in resort medicine].

Carboxytherapy (the treatment based on carbon dioxide injections) is a multipurpose and widely used medical technology. The use of CO injections (intracutaneous, subcutaneous, and pneumopuncture) have substantially supplemented and increased the practical relevance of carboxytherapy as a method for the treatment of many diseases. Thanks to it physiological properties, CO has antihypoxic, antioxidant, vasodilatory, anti-inflammatory, analgesic, and spasmolytic activities; moreover, it improves blood viscosity, stimulates neoangiogenesis, and regenerative processes.

Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?

We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.

[CIRCADIAN DEPENDENCE OF PARACETAMOL HEPATOTOXICITY IN RATS.].

Results of chronopharmacological study of the circadian dependence of paracetamol toxicity and the extrapolation of obtained results to determine peculiarities in the daily activity of metabolic processes in rat liver are reported. The study was conducted on the model of acute paracetamol-induced hepatitis in both male and female rats in four diual periods: 03.00 a.

[The liver-protective properties of the pediatric drug form of propolis in animals of different age groups].

The pharmacological activity of a pediatric formulation of the phenolic hydrophobic drug propolis was studied in the experiments on albino rats of various age with toxic liver damages of various duration and in acute hepatic ischemia. In all models of hepatic abnormalities, the drug was found to show antioxidative properties which were moderate (30-60%). In addition, there were improvements in hepatic secretion of bile, cholic acids, and cholesterol.

[An experimental study of suikrepan].

Acute, subacute, and chronic experiments were performed to examine the toxicity, specific action, analgetic, and physicochemical properties of suicrepan derived from the porcine duodenal mucosa and the hormone secretin contained in it. Suicrepan was found to be an effective pancreatic extrasecretory function stimulant, by showing therapeutical benefits in experimental pancreatitis and analgesic effects. The drug was demonstrated to display a low toxicity.

[The tocolytic activity of melatonin].

Melatonin was shown to produce a tocolytic effect in experiments on the isolated uterine horn in different experimental animals and on the whole body. The ability of melatonin to inhibit uterine contractility was confirmed by the studies of the effects of melatonin on oxytocin-induced myometrial contractions. It may be suggested that the antagonism between melatonin and oxytocin is uncompetitive.

[The effect of the amino sugar glucosamine on the endogenous intoxication processes in pulmonary edema in rats].

The effects of glycosamine aminosugar on the processes of endotoxicosis and lipid peroxidation were thoroughly studied in rats with toxic pulmonary edema. There was a glycosamine-induced decrease in markers of endotoxicosis, such as medium-weight molecular peptides and malonic dialdehyde in serum and lung tissue. Administration of exogenous glucosamine resulted in its incorporation into the membranes of target organs, connective tissue and normalized the levels of endogenous N-acetyl-glucosamine, which finally determined antitoxic and antioxidative properties in this aminosugar.

[The efficacy of hydroxycinnamic acids in toxic lesions of the liver].

The albino rat experiments studied the pharmacological action of oxycinnamic acid derivatives in acute tetrachloromethane-induced hepatic dystrophy and combined CCl4-ethanol-induced hepatic lesion. The tested agents were found to produce cholagogic, membrane-protective, and antioxidative effects in these hepatic abnormalities, thus improving the functional (cholate- and glycogen-synthetic) parameters of the liver.

[Antihypoxic effect of glucosamine in acute hypoxic states in mice].

The preventive glucosamine injection causes an increase in the survival of mice with acute hypobaric hypoxia. The injection of glucosamine, combined with sodium hydroxybutyrate greatly increased their antihypoxic activities.

[The effect of the new nonsteroidal anti-inflammatory agent glucamine on oxidative phosphorylation processes].

A study was made of the action of the nonsteroidal antiinflammatory agent glucamin on the processes of oxidation and phosphorylation (OP) in isolated mitochondria of the liver. It has been established that glucamin does not exhibit the properties of a separator in the explored concentrations (10(-2)-10(-7) M). Unlike the standard drug voltaren that separates OP processes, it slightly enhances interaction of liver mitochondria which oxidize NAD-dependent substrates.

[The influence of glucosamine on the antiexudative effect of nonsteroidal anti-inflammatory agents].

The study of the antiexudative activities of voltaren, indomethacin and piroxicam in combination with glucosamine on the model of carrageenan inflammation showed that the combination makes it possible to decrease the effective doses of nonsteroidal anti-inflammatory drugs by 2-2.7 times with the preservation of the pronounced antiexudative activity. A diverse influence of aminosugar on the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs depending on the sequence and routes of administration is connected with their membrane mechanisms and metabolic features of amino sugar.

[The efficacy of glucosamine in treating complicated hyperreactive experimental myocardial infarct].

The effect of glucosamine hydrochloride on the course of complicated hyperreactive myocardial infarction in dogs was studied. Glucosamine contributed to the restoration of reactivity in the animals. The reactivity became corresponding for normoreactive myocardial infarction.

[The liver-protective properties of D-glucosamine].

The antioxidant and membrane-stabilizing activities of D-glucosamine were studied on two models of toxic liver damage. When administered in a dose of 50 mg/kg, D-glucosamine was found to prevent the development of the hepatocyte cytolysis syndrome, to normalize the cholate- and glycogen-synthetic functions of the liver. D-glucosamine exhibited a significant anabolic effect that also supplemented its hepatoprotective activity.

[Physiologic importance of glucosamine].

The paper reviews the present state of the problem on the physiological importance of D-(+)-glucosamine, an amino sugar. Glucosamine is shown to be a component of many biological important systems widely spread in nature. It is a part of the connective tissues, membranes, lipopolysaccharides and mucopolysaccharides and participates in detoxic function of the liver and kidneys.

[The hepatotropic properties of nonsteroidal anti-inflammatory agents].

The hepatotropic effect of nonsteroidal anti-inflammatory drugs (NSAID) such as indomethacin, voltaren, piroxicam, phenylbutazon, mefenamic acid was studied. It was found that according to their level of the pharmacological protection of the liver against tetrachlormethan these agents may be arranged in the following sequence: mefenamic acid, phenylbutazon, voltaren, piroxicam. The hepatoprotective effect of NSAID correlates with the antioxidant properties and fails to correlate with the antioxidant ones.

[Interrelation of the antialterative and antiproliferative effects of indomethacin, voltaren, piroxicam and D-glucosamine].

In experiments on rats it was shown that voltaren had a moderate degree and D-glucosamine a pronounced degree of antiproliferative and antialterative effects. On these models indomethacin and piroxicam also exerted a marked antiproliferative action and the ability to suppress tissue regeneration in alterative inflammation.

[Hepatoprotective and antioxidative activity of some methoxy- and nitroderivatives of acridinyl-9-thioacetic acids].

During experiments on rats it was established that some methoxy- and nitro-derivatives of acridinyl-9-thioacetic acids possess the hepatoprotective properties contributing to a decrease of the liver tissue cell destruction under the action of CCl4 and lipid peroxidation in the liver.

[Action of hepatoprotective agents in a tetracycline lesion of the liver].

Comparative efficacy of hepatoprotective agents in tetracycline affection of the liver is discussed. The affection was induced by daily intragastric administration of the antibiotic in a dose of 0.5 g/kg body weight to Wistar albino rats.

[Search for anti-inflammatory preparations among the derivatives of succinic acid heteryl amides].

The antiinflammatory activity and acute toxicity of 44 derivatives of heteryl amides of succinic acid (acids, esters, amides) were studied. This series of compounds was found to be promising for the search of nonsteroidal, practically nontoxic antiphlogistics. The structural-pharmacological analysis was performed and the dependence of the biological effect on the compound structure was revealed.