Publications by authors named "Drochss Pettry Valencia-Ochoa"
Article Synopsis
- - The study investigates various bis-substituted tetrandrine derivatives and their binding properties to double-stranded DNA (dsDNA) using techniques like UV-vis and fluorescence, revealing their high affinity for dsDNA, especially the bis(methyl)anthraquinone (BAqT) and bis(ethyl)indole (BInT) derivatives, with binding constants around 10^-10 M.
- - Utilizing viscometry, ethidium displacement assays, and molecular modeling, researchers identified that these compounds interact with dsDNA through a dual mechanism involving intercalation and major groove binding.
- - Cytotoxicity tests showed low toxicity for most derivatives against various cell lines, except for the bis(methyl)pyrene (
