Publications by authors named "Dristi Adhikari"

Background: The apathy evaluation scale (AES) measures apathy, but its usefulness as a screening tool in diverse populations is limited without translation into more languages. To date, there is no reported translation of the AES into Malayalam, a language spoken by over 32 million people in the southern Indian state of Kerala. In the present study, we aimed to validate the Malayalam version of the AES.

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  • The study investigates the relationship between sleep disturbances and the risk of developing motoric cognitive risk syndrome (MCR), which includes cognitive complaints and slow walking speed, in older adults.
  • Researchers analyzed data from 445 community-residing adults aged 65 and older to see how sleep quality impacted both the onset and prevalence of MCR.
  • Results indicated that poor sleepers were initially at a higher risk for developing MCR, but this link weakened after considering the influence of depressive symptoms.
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  • The study explored how happiness affects health outcomes in older adults, focusing on 665 participants from Kerala, India, and looked at various demographic, health, and lifestyle factors.* -
  • Key findings revealed that happiness was significantly linked to self-rated health, social networks, and mental health factors like depression and anxiety, while traditional demographic factors didn't show a strong connection.* -
  • Additionally, certain brain regions associated with happiness were identified, suggesting a complex relationship between brain structure and subjective well-being that may help explain happiness's resilience against age-related decline.*
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  • Motoric cognitive risk syndrome (MCR) is a pre-dementia condition marked by cognitive complaints and slow walking, which correlates with difficulties in daily activities.
  • A study compared 46 older adults who developed MCR to 264 who remained cognitively intact, revealing that those in the pre-MCR stage faced significant challenges in complex tasks like managing finances and hobbies.
  • The findings indicate that these functional limitations can appear before a formal diagnosis of MCR, highlighting the importance of monitoring daily activity difficulties as early risk indicators.
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  • The Kerala Einstein Study (KES) is a research project aimed at understanding the early stages of cognitive decline, specifically the motoric cognitive risk syndrome (MCR), in older adults living in Kerala, India.
  • Initiated in 2008, the study plans to enroll 1,000 individuals aged 60 and above to identify risk factors related to MCR and compare profiles between urban and rural populations.
  • The research includes comprehensive assessments of cognitive and physical functions, medical backgrounds, lifestyle habits, and imaging tests to gather data on the prevalence and implications of predementia syndromes like MCR in the aging population of Kerala.
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Objective: Motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and subjective cognitive concerns, is associated with multiple age-related risk factors. We hypothesized that MCR is associated with biological age acceleration. We examined the associations of biological age acceleration with MCR, and mortality risk in MCR cases.

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Community pharmacies in Nepal and other South Asian countries are in a mediocre state due to poor regulation and the fact that many pharmacies are run by people with insufficient training in dispensing. This has led to the inappropriate use of medicines. The problems due to poor regulation and the mediocre state of community pharmacies in South Asia encompass both academia and clinical practice.

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