Psychosocial Factors Affecting Wellbeing and Sources of Support of Young Adult Cancer Survivors: A Scoping Review.

Background/objectives: To identify and analyze what is known about the psychosocial factors affecting the wellbeing and sources of support of young adult (YA) cancer survivors.

Methods: The search strategy included Neoplasms, young adults, psycho* or emotional well* or mental health. The OVID Medline and CINAHL databases were searched.

Obesity in Hidradenitis Suppurativa: Are GLP-1 Receptor Agonists the New Frontier?

Hidradenitis suppurativa (HS) is an inflammatory skin disorder presenting with painful and draining nodules in intertriginous areas that may progress to sinus tracts. There is an increased prevalence of obesity in HS, and obesity may predispose patients to HS. Weight loss has been associated with improvement of HS symptoms.

Feasibility of a novel back support device to improve spine stability and muscular activity during trunk flexion: A prospective cross-sectional study with healthy controls and low back pain subjects - preliminary.

Background: Low back pain is a prevalent global condition often challenging to address due to the absence of a definitive diagnosis in over 80 % of cases. Manual lifting, common in many work environments, contributes to low back pain due to lumbar spine stresses, and existing assistive technologies like abdominal belts and exoskeletons have limitations in managing low back pain effectively. This paper presents a novel back support device designed to generate abdominal compression during flexion activities, potentially enhancing lumbar stability through increased intra-abdominal pressure.

BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells.

Background: Bone morphogenetic protein (BMP) signaling cascade is a phylogenetically conserved stem cell regulator that is aberrantly expressed in non-small cell lung cancer (NSLC) and leukemias. BMP signaling negatively regulates mitochondrial bioenergetics in lung cancer cells. The impact of inhibiting BMP signaling on mitochondrial bioenergetics and the effect this has on the survival of NSLC and leukemia cells are not known.

Factors associated with participation in a walking intervention for veterans who smoke and have chronic pain.

This analysis was part of the Pain and Smoking Study (PASS), a randomized trial of a cognitive behavioral intervention (CBI) for Veterans with chronic pain who smoke. The objective of this study was to examine factors associated with participation in the walking component of the intervention. Demographics and clinical characteristics were obtained at baseline.

Unconstrained dynamic gel swelling generates transient surface deformations.

Polymer gels are comprised of a three-dimensional, cross-linked network that can typically withstand the mechanical deformation associated with both swelling and de-swelling. Thus, gels can be designed with smart behaviors that require both stress generation and dissipation, making them well-suited to many applications including membrane technology, water capture devices, and drug delivery systems. In contrast to the fully swelled equilibrium state, limited research characterizes the unsteady-state swelling regime prior to equilibrium.

Ethnic-racial identity latent profiles protect against racial discrimination in Black American adults.

This study examined how ethnic-racial identity (ERI) profiles moderate the relationship between racial discrimination and mental health among Black American adults. Black American adults ( = 247) recruited from a community-based sample completed self-report measures of ERI, racial discrimination, depression, psychological distress, and emotional well-being. Latent profile analysis (LPA) identified four distinct ERI profiles, corresponding to the ERI status theorized in prior research-Diffusion, Moratorium, and Achievement-and a fourth profile, which corresponded to an ERI status for High Achievement.

Unveiling surgical expertise through machine learning in a novel VR/AR spinal simulator: A multilayered approach using transfer learning and connection weights analysis.

Background: Virtual and augmented reality surgical simulators, integrated with machine learning, are becoming essential for training psychomotor skills, and analyzing surgical performance. Despite the promise of methods like the Connection Weights Algorithm, the small sample sizes (small number of participants (N)) typical of these trials challenge the generalizability and robustness of models. Approaches like data augmentation and transfer learning from models trained on similar surgical tasks address these limitations.

Drop impact dynamics of complex fluids: a review.

The impact of fluid drops on solid substrates has widespread interest in many industrial coating and spraying applications, such as ink-jet printing and agricultural pesticide sprays. Many of the fluids used in these applications are non-Newtonian, that is they contain particulate or polymeric additives that strongly modify their flow behaviour. While a large body of experimental and theoretical work has been done to understand the impact dynamics of Newtonian fluids, we as a community have much progress to make to understand how these dynamics are modified when the impact fluid has non-Newtonian rheology.

Proteolysis-free amoeboid migration of melanoma cells through crowded environments via bleb-driven worrying.

In crowded microenvironments, migrating cells must find or make a path. Amoeboid cells are thought to find a path by deforming their bodies to squeeze through tight spaces. Yet, some amoeboid cells seem to maintain a near-spherical morphology as they move.

Comorbid Chronic Pain and Post-traumatic Stress Disorder: Current Rates and Psychiatric Comorbidities Among U.S. Military Veterans.

Introduction: This study reports rates of comorbid chronic pain and post-traumatic stress disorder (PTSD) among U.S. military veterans and rates of psychiatric comorbidities among those with both chronic pain and PTSD.

The coupling between healthspan and lifespan in depends on complex interactions between compound intervention and genetic background.

Aging is characterized by declining health that results in decreased cellular resilience and neuromuscular function. The relationship between lifespan and health, and the influence of genetic background on that relationship, has important implications in the development of pharmacological anti-aging interventions. Here we assessed swimming performance as well as survival under thermal and oxidative stress across a nematode genetic diversity test panel to evaluate health effects for three compounds previously studied in the Intervention Testing Program and thought to promote longevity in different ways - NP1 (nitrophenyl piperazine-containing compound 1), propyl gallate, and resveratrol.

Mechanical Evaluation of Human Cadaveric Lumbar Soft Tissues Suggests Possible Physiological Stress Shielding Within Musculoskeletal Soft Tissues by the Thoracolumbar Fascia.

Objective: This study investigates the potential for stress shielding within musculoskeletal soft tissues through analysis of stress distributions between lumbar fascial and muscle tissues via mechanical testing.

Methods: Using a custom apparatus, 51 posterior thoracolumbar fascia (TLF) samples and 18 erector spinae (ES) cadaveric samples underwent tensile testing involving three loading-unloading cycles, followed by loading to 6% strain, to mechanically characterize samples. Parallel tensile testing using 20 pairs of two TLF samples, and seven pairs of TLF and ES samples was then conducted for stress distribution analysis between tissues.

Efficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment.

Background: Chronic pain is common among individuals with opioid use disorder (OUD) who are maintained on medications for OUD (MOUD; eg, buprenorphine or methadone). Chronic pain is associated with worse retention and higher levels of substance use. Treatment of individuals with chronic pain receiving MOUD can be challenging due to their increased clinical complexity.

Improved DNA Extraction and Amplification Strategy for 16S rRNA Gene Amplicon-Based Microbiome Studies.

Next-generation sequencing technology has driven the rapid advancement of human microbiome studies by enabling community-level sequence profiling of microbiomes. Although all microbiome sequencing methods depend on recovering the DNA from a sample as a first critical step, lysis methods can be a major determinant of microbiome profile bias. Gentle enzyme-based DNA preparation methods preserve DNA quality but can bias the results by failing to open difficult-to-lyse bacteria.