A randomized trial to reduce smoking among American Indians in South Dakota: The walking forward study.

Background: Lung cancer is an important public health issue, particularly among American Indians (AIs). The reported decline in tobacco use for most racial/ethnic groups is not observed among AIs. This project was designed to address the research question, "Why don't more Northern Plains American Indians alter tobacco use behaviors known to increase the risk of cancer?"

Methods: Guided by the Theory of Planned Behavior, a multi-component intervention study was implemented.

Reality Versus Grant Application Research "Plans".

This article describes the implementation of the American Indian mHealth Smoking Dependence Study focusing on the differences between what was written in the grant application compared to what happened in reality. The study was designed to evaluate a multicomponent intervention involving 256 participants randomly assigned to one of 15 groups. Participants received either a minimal or an intense level of four intervention components: (1) nicotine replacement therapy, (2) precessation counseling, (3) cessation counseling, and (4) mHealth text messaging.

Evidence for a second messenger function of dUTP during Bax mediated apoptosis of yeast and mammalian cells.

The identification of novel anti-apoptotic sequences has lead to new insights into the mechanisms involved in regulating different forms of programmed cell death. For example, the anti-apoptotic function of free radical scavenging proteins supports the pro-apoptotic function of Reactive Oxygen Species (ROS). Using yeast as a model of eukaryotic mitochondrial apoptosis, we show that a cDNA corresponding to the mitochondrial variant of the human DUT gene (DUT-M) encoding the deoxyuridine triphosphatase (dUTPase) enzyme can prevent apoptosis in yeast in response to internal (Bax expression) and to exogenous (H(2)O(2) and cadmium) stresses.

Dynamic plantar pressure parameters associated with static arch height index during gait.

Background: Although extreme values of arch height have been associated with increased risk for overuse injury, knowledge is limited regarding the association between arch height and plantar pressure distributions during gait. The primary purpose of this study was to explore which plantar pressure measurements during gait were associated with static arch height and arch height index.

Methods: Static arch height, arch height index, and dynamic plantar pressure distributions were collected for 1000 subjects (566 males, 434 females, 30.

Linking growth, survival, and heterogeneity through vitality.

We model the cross-stage effect of juvenile growth on future cohort survival with vitality, a single stochastic measure of an organism's survival capacity that results in death when it reaches 0. In this construct, the distribution of vitality at the end of a growth treatment stage, which is a measure of survival capacity heterogeneity, determines a cohort's susceptibility to starvation in a subsequent challenge stage. The model predicts that the treatment-stage duration and mass gain determine the mean and variance of the initial vitality distribution of the challenge stage, which in turn determine the effect of a challenge-stage stressor on survival.