Tenogenically differentiated adipose-derived stem cells are effective in Achilles tendon repair in vivo.

The purpose of this study was to characterize rat adipose-derived stem cells, induce adipose-derived stem cell tenogenesis, and analyze adipose-derived stem cell effects on tendon repair in vivo. Adipose-derived stem cells demonstrated an immunomodulatory, pro-angiogenic, and pro-proliferatory profile in vitro. Tenogenesis was induced for 1, 7, 14, and 21 days with 24 combinations of growth differentiation factor-5, 6, and 7 and platelet-derived growth factor-BB.

Biomechanical evaluation of a new MatrixMandible plating system on cadaver mandibles.

Purpose: Current mandibular plating systems contain a wide range of plates and screws needed for the treatment of mandibular reconstruction and mandibular fractures. The authors' hypothesis was that a single diameter screw could be used in all applications in a plating system. Therefore, the purpose of this study was to test if the 2.

A comparative, long-term assessment of four soft tissue substitutes.

Background: The ideal product for soft tissue replacement is durable, nonimmunogenic, and noninfectious. AlloDerm (LifeCell Corp., Branchburg, New Jersey), Enduragen (Stryker Corp.

The flexion-extension axis of the knee and its relationship to the rotational orientation of the tibial plateau.

We measured the optimal rotational alignment of the tibial component with respect to anatomic landmarks. Kinematic data were collected from functional maneuvers simulated in 20 cadaveric knees mounted in a joint simulator. The axis of knee motion was calculated for squatting and lunging activities over the interval of 30° to 90° of knee flexion.

Nonoperative management of complex burn injuries.

Severe burn injuries frequently present a therapeutic challenge; fortunately, conservative therapies have proven highly effective in augmenting standard surgical management. Skin substitutes, such as pigskin or cadaveric tissue, aid in acute burn care by limiting fluid and heat loss. In the subacute phase, splint therapy provides direct pressure, maintains soft tissue form at specific areas, and limits scarring.

Ethical considerations in burn management.

Catastrophic burn injuries often leave patients in shock or incommunicative, creating complex ethical situations. Patient autonomy and the ability to make competent decisions become key issues. Although patient surrogates may aid in decision making, few patient advocates possess appropriate perspective of burn injury, management options, and likely outcomes.

Orbitozygomatic fracture management.

Orbitozygomatic fractures are frequently encountered in plastic surgery. Management depends on a thorough preoperative physical examination, with attention to the ophthalmologic assessment. Coronal and axial computed tomography is essential for identifying fracture extent and orbital involvement.