Publications by authors named "Drew Siegel"
Gynecol Oncol
October 2023
Article Synopsis
- - The study investigates the link between germline pathogenic variants in the PALB2 gene and the development of ovarian cancer, given that 20% of ovarian cancers are hereditary.
- - A systematic review and meta-analysis were conducted, analyzing 55 studies with data from nearly 48,194 ovarian cancer patients, revealing that only 0.4% had PALB2 pathogenic variants.
- - The findings suggest that individuals with ovarian cancer are 2.48 times more likely to carry PALB2 pathogenic variants compared to the general population, indicating the need for further research on this gene's role in ovarian cancer.
