Publications by authors named "Drew A Vander Wood"
Article Synopsis
- The term "module" is redefined in the context of trans-acyltransferase assembly lines, focusing on the cooperation and evolutionary relationship of its domains.
- The acyl carrier protein (ACP) is identified as a key player in both polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) assembly lines, facilitating the transfer of acyl chains and collaborating with other enzymes to add specific chemical groups.
- Bioinformatic analysis of 526 ACPs reveals that ACPs from the same module type tend to evolve together with their enzymes, suggesting a need to reconsider traditional definitions of modules for better understanding of assembly line functionality and engineering.
