[Comparative characteristics of the activity of enzyme systems for nitrogen metabolism in the liver of human fetuses during embryogenesis].

The activities of alanine aminotransferase (ES 2.6.1.

[Amino acid metabolism in the human placenta during its functional maturation].

The total content of free amino acids in chorion villi of the 7-40-week human placenta rises from 41 up to 71 mg%, which is mostly due to an increase in the content of replaceable amino acids. In the process of development the intensity of glutaminic acid desamination changes essentially and correlates with changes in its content in the placenta. The aspartate and alanine aminotransferase activity in the placenta during the period under study rises almost twice, that correlates with changes in the content of alanine, glutaminic and asparginic acids in the corresponding periods of development.

[Nitrogen metabolism in salmonellosis in man and animals].

The data obtained make it possible to understand more clearly some aspects of pathogenesis of salmonollosis bacterium carriage and testify to the fact that disturbances in nitrogen metabolism in tissues are essential in development of its different morphological and clinical manifestations.

[Formation of some enzymic systems in the human fetal brain during development].

The data of studies in the monoaminoxidase, nuclease and transaminase activity in fractions of mitochondria and nuclei of the human fetus brain in the process of the fetus development evidence for the changes in the activity depending on the morphological and functional maturation of the organ during the antenatal ontogenesis. The monoaminoxidase activity increases by the time of birth. By the 40th week of development the activity of glutamic-aspartic transaminase increases as well.

[Enzymes of anabolic and catabolic nucleic acid pathways in human hepatomas, in liver of healthy persons, and in liver of patients with cancer of gastrointestinal tract].

The activities of enzymes catalyzing the formation of nucleic acid precursors, nucleoside kinases, as well as of those involved in the degradation of nucleic acids, were studied in nuclei of the liver of healthy persons, human hepatomas and the liver of patients with cancer of gastrointestinal tract. The activities of thymydine kinase and uridine kinase in the human hepatoma nuclear sap were found to increase 40- to 50-fold and 120- to 150-fold, respectively, as compared to those in normal human liver. The activities of DNase and RNase in the fraction of chromatin protein of human hepatomas, on the contrary, decreased almost to zero.

[State of the sympathetic-adrenal system in newborn infants (clinico-biochemical comparisons)].

A study was made of urinary catecholamine excretion in 102 newborn boys on the 1st-8th day after birth. Depending on the state at birth neonates were divided into 2 groups: the 1st group included babies born in satisfactory condition (60), and the 2nd group - at the state of mild asphyxia. Catecholamines were determined on the 1st-2nd, 3rd-5th, and 6th-8th days after birth.

[Lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity in the erythrocytes in diabetes mellitus].

In human erythrocytes activities of glucose-6-phosphate and lactate dehydrogenases were decreased approximately 2-fold in moderately severe and critical forms of diabetes mellitus, as compared with normal state. The lactate dehydrogenase activity was more distinctly decreased than the glucose-6-phosphate dehydrogenase activity. General medical treatment increased the activity of the enzymes (which catalyzed the ATP formation in erythrocytes) and normalized their relation.

[A comparative study of activity of nucleic acid metabolism in human embryonic liver].

In nuclei of hepatocytes of human embryos from the 18th to 40th week of antenatal development the activity of synthesis enzymes lowers: thymidine kinase is 7 times at low, uridine kinase - 11 times as low. In parallel during the same period a decrease in the activity of nucleases drops: DNase - by 15 times, RNase - by 11 times. The activity of these enzymes in the liver of adult persons (22-35 years old) is similar to their activity in the liver of human embryo to the moment of birth.