[Long-term mexiletine treatment of ventricular arrhythmia in patients after myocardial infarction].

Eighty two patients with ventricular extrasystole (VES) after myocardial infarction had been treated with antiarrhythmic drugs in the half (41 patients) with mexiletine (M) and in the half (41 patients) with other ones. The mortality rate in the M-group was twice time lower than in the other, however this difference was statistically not significant. M was mostly effective in VES of III and IVb degree after Lown's classification and did not cause any deterioration of the left ventricle function.

Connective tissue ultrastructure in patients with acquired valvular heart disease following endocarditis.

Tissue samples taken during surgery for therapeutic reasons from patients with acquired valvular heart disease (a.v.h.

The dynamics of isolated systolic hypertension during the 10-year period of geriatric treatment.

The aim of the study was to analyse the course of isolated systolic hypertension in old age and its influence upon quoad vitam prognosis. A group of 100 persons over 60 was chosen and observed systematically for the period of 10 years in the geriatric out-patients centre. On the basis of pattern of arterial pressure in the 10-year-period the patients were qualified into several types of hypertension.

Histopathological studies of connective tissue in patients with acquired valvular heart disease.

Tissue samples taken during a surgical procedure performed for therapeutic reasons in 27 patients with acquired valvular heart disease (a.v.h.

Investigations upon collagen metabolites in blood serum and urine of patients with acquired valvular heart disease.

In 45 patients suffering from acquired valvular heart disease (a.v.h.

Collagen content in the heart of patients operated on for valvular heart disease caused mainly by infective endocarditis.

Collagen from tissues of the heart valve, the wall of the left auricle, palatine tonsils and periodontium was studied. The material was taken during surgical procedures, performed for therapeutic reasons, in patients with acquired valvular heart disease (avhd) and congenital heart disease. The obtained results pertain to the content of total collagen as well as to its soluble and insoluble fractions.

Determination of immune complexes in patients with acquired valvular heart disease.

The authors investigated the incidence of circulating immune complexes (CIC) in 52 patients with acquired valvular heart disease (VHD) and in 50 control blood donors. There was a statistically significant relationship between the CIC occurrence in patients with VHD and the presence of an active process in endocardium. However, no relation was found between the presence of CIC and heart operations, enucleation of palatine tonsils and the past history of rheumatic disease.