Publications by authors named "Drazen Cavuzic"
Article Synopsis
- The accuracy of reference values is crucial for the quality of near-infrared (NIR) models used in determining water content in freeze-dried meningococcal vaccines.
- A new analytical method was developed, and an experimental design called the standard addition method (SAM) was employed to assess both calibration uncertainties and systematic errors from the reference Karl-Fischer method.
- The NIR model effectively measured water content within a range of 1.0-6.7% and demonstrated a slope of 1.01 in proportional error assessment, confirming its superiority over the reference method for evaluating water content variability and stability.
Near-infrared (NIR) spectroscopy is an attractive tool for pharmaceutical analyses. The main purpose of this study was to assess the potential of NIR spectroscopy coupled with different multivariate classification tools for the identification of meningococcal polysaccharide serogroups A and C. Moreover, it sought to determine, if the models established on production batches, could be used to correctly identify National Institute for Biological Standards and Control standards.
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