Publications by authors named "Dragos Zamfirescu"

Article Synopsis
  • The field of transplantation has advanced significantly since the first hand transplant in 1998, particularly in vascularized composite allotransplantation (VCA), which faces challenges like the need for lifelong immunosuppressive therapy.
  • Current research aims to improve immunosuppressive strategies to reduce toxicity and foster donor-specific tolerance, emphasizing the role of costimulatory signals in T cell activation.
  • This review summarizes data on costimulatory blockade as a potential method to prevent organ rejection and enhance the success of VCA, exploring new techniques for safer transplantation procedures.
View Article and Find Full Text PDF

Treatment of tibial defects with important soft tissue involvement after bilateral lower limb trauma are challenging for both orthopedic and plastic surgeons. Several therapeutic options are described in armamentarium of reconstructive surgeons such as bone grafts, bone substitutes, distractions osteogenesis, limb prosthesis, free flaps, negative pressure therapy and unfortunately amputation. We describe a patient with tibial and soft tissue defect reconstructed using a chimeric flap composed of latissimus dorsi, serratus anterior muscle and two ribs.

View Article and Find Full Text PDF

Introduction: Despite hundreds of training models for microsurgery being available in the literature, very few of them are scientifically validated. We chose to validate our low-fidelity training model on flower petals by comparing it head-to-head with a moderate fidelity training model, the anastomosis on chicken leg femoral artery.

Materials And Methods: A total of 16 participants of different levels of expertise were randomized into 2 groups, 1 training on flower petals and 1 on chicken leg femoral arteries.

View Article and Find Full Text PDF

Glomus tumors are frequently associated with pain, tenderness and cold sensitivity. We report the diagnosis and successful surgical management of a case of a classic glomus tumor in a young woman. The clinical diagnosis was made on the basis of medical history and MRI findings.

View Article and Find Full Text PDF

Giant cell tumor of bone (GCTB) represents one of the commonest bone tumors encountered by an orthopedic surgeon. The giant-cell tumor is generally classified as benign but the fast growing rhythm and the aggressive soft-tissue invasion may in some cases demonstrate a malign potential of the tumor. We present the case of an aggressive giant cell tumor in a young patient that was first diagnosed in our emergency department with a fracture of the distal femur after a low energy trauma.

View Article and Find Full Text PDF

Background: Vein anastomosis is the most important factor determining the success in the replantation of distal phalanx amputations. It is very difficult to find the collapsed veins and to perform vein anastomosis immediately after arterial repair. We have chosen to delay the vein repair between 30 minutes and 1 hour to give time to the veins to expand to a more reasonable diameter for repair.

View Article and Find Full Text PDF

Hematopoietic stem cell transplantation (HSCT) is a a standard therapeutic option for several diseases. The success of the procedure depends on quality and quantity of transplanted cells and on stromal capacity to create an optimal microenvironment, that supports survival and development of the hematopoietic elements. Conditions associated with stromal dysfunction lead to slower/insufficient engraftment and/or immune reconstitution.

View Article and Find Full Text PDF

This article presents a comparison of microsurgical training of groups with different background. A protocol based on the rat femoral arterial anastomoses was used to provide an objective representation of the microsurgical skills progress. The performance is assessed by consistent (x4) patency of a standardized anastomosis.

View Article and Find Full Text PDF