Light scattering in the human lens in childhood and adolescence.

The age-related increase in normal light scattering in the adult human lens has frequently been documented with Scheimpflug imaging techniques. There are only insufficient data on lens light scattering, however, from the first 2 decades of human life. After having obtained informed consent from their parents, the anterior eye segments of 26 children of both genders were documented with a Topcon SL-45 Scheimpflug camera on Kodak Tmax 400 ASA black-and-white film in 3 meridians.

Rotating slit image camera TOPCON SL 45. New developments for simultaneous image acquisition by photographic and CCD-assisted on-line documentation.

In a first approach the photographic camera part of the SL 45 B has been replaced by a CCD camera (2/3" black-and-white camera/Teli CS 3440 CCD B/W Tokyo Electronic Industry Co., Ltd.) unit thus enabling direct image acquisition and computer assisted analyses.

Improved biometry of the anterior eye segment.

In this paper, a method is presented to evaluate the true values of several optical parameters of the anterior eye segment. These are: the thicknesses of the cornea and lens, the depth of the anterior chamber and the anterior and posterior curvatures of the cornea and lens. First, a photo is taken of each patient's eye with a Topcon SL-45 Scheimpflug camera.

Biochemical analysis of bovine lens sections obtained by a new sectioning device.

One mm thick layers were reproducibly sliced from the punched-out inner cylinder of bovine lenses. The layers were obtained by a special designed freeze-sectioning device. Biochemical analysis of these layers revealed a detailed picture of the lenticular distribution of the amount of water-insoluble and urea-insoluble fractions.

Monitoring lens transparency during in vitro incubation by Scheimpflug photography and densitometric image analysis.

Dragomirescu et al. [1983] described a 2-chamber flow system for the incubation of lenses with an inserted photometer to measure changes in lens transparency. Mester et al.

[Biometry of the lens with respect to age and cataract morphology. Evaluation of Scheimpflug photos of the anterior segment].

Thickness of the lens, cortex and nucleus or nucleus with supranuclear layer, respectively, were determined for 58 controls aged 11-69 years (115 lenses), and for 175 patients aged 30-86 years with different types of cataract (247 lenses). Measurements of the densitograms of Scheimpflug photos (taken along the optical axis, magnified 10-fold) were performed, accurate to 0.5 mm (corresponding to 0.

Evaluation of the ocular safety of verapamil. Scheimpflug photography with densitometric image analysis of lens transparency in patients with hypertrophic cardiomyopathy subjected to long-term therapy with high doses of verapamil.

The ophthalmic examination of patients with hypertrophic cardiomyopathy treated with high doses of verapamil over a considerable period of time showed no evidence of a side effect of the drug, thus proving its ocular safety. This could be verified by densitometric image analysis of Scheimpflug photographs of the eyes. The data were used for statistical tests on lens transparency.

Long-term follow-up examination of experimental cataracts in rats by Scheimpflug photography and densitometry.

Development of experimental cataract can be objectively monitored in rats by application of Scheimpflug photography with the SL 45 Topcon camera and subsequent densitometric image analysis. The method has been used to study naphthalene cataract in Brown-Norway rats (BN-CPB), as well as diabetic cataract induced by streptozotocin injection in Sprague-Dawley rats. The values obtained by linear microdensitometric image analysis allowed precise characterization of the opacification with respect to size, topography, and time progress so that statistical evaluation of the efficacy of certain drugs in prevention or delay of experimental cataracts was possible.

Biometry of the anterior eye segment by Scheimpflug photography.

Scheimpflug photos of 262 cataract patients, classified according to various forms of opacifications characteristic for senile cataracts were evaluated by biometric methods. The measured values on cornea thickness, depth of anterior chamber, lens thickness, and radii of curvatures of cornea and anterior lens surface show that a correlation between some of the parameters and certain forms of opacities must be assumed.

In vitro incubation of lenses: a model for investigations on lens transparency by varying the perfusion rate, osmolarity and temperature of the culture medium.

A Beckman photometer was modified so that the unfiltered beam of a tungsten lamp could pass vertically through a special chamber. This particular chamber, containing two compartments, allowed certain modifications of the incubation conditions with respect to the anterior and/or posterior lens surface. The temperature of the incubation media was variable between 15 degrees and 37 degrees C; they were led into the chamber by hose gauge at different perfusion rates.

Measurements of lens transparency or its disturbances by densitometric image analysis of Scheimpflug photographs.

Scheimpflug photography of the anterior eye segment with densitometric image analysis to measure lens transparency has proven its value in long-term follow-up studies of lens changes. The necessary technical conditions of the SL 45 Topcon camera guarantee high reproducibility. The technical control with respect to quality in case of repeated photography is ensured by an internal standard, the camera being equipped with a five-step scale of known density values.