Triple drug chemotherapy in treatment of prostate adenocarcinoma Nb Pr A.I.-III.

The combination of cyclophosphamide, cis-platinum, and adriamycin has been evaluated in the Nb tumor model system. Triple drug therapy has resulted in marked reduction in tumor volume (P less than 0.01), as well as decreased number of metastases (P less than 0.

Bilateral ureteropelvic junction avulsion after blunt abdominal trauma.

Ureteral pelvic junction avulsion can occur after deceleration injury. A case of this type of injury is presented herein, as well as a review of the literature.

Ureteral avulsion from non-penetrating trauma.

We report 6 instances of complete ureteral avulsion in 5 patients undergoing acute acceleration/deceleration trauma. One patient also had an unsalvageable contralateral renal arterial intimal injury. In all instances the ureteral avulsion injury was repaired successfully and in 4 patients only 1 surgical procedure was used.

Therapy for Nb rat tumor transplanted in athymic mice.

Two Nb rat prostatic adenocarcinomas, 13 Pr-12, an autonomous tumor, and 2 Pr-128, an androgen-dependent tumor, were transplanted into groups of congenitally athymic nude mice. The agents used for treatment of these tumors are agents characteristically not used in treatment of prostatic adenocarcinoma in humans. However, these have been efficacious in treating other solid malignancies.

Treatment of an Nb-Pr-A.I.-3 (autonomous) tumor with combination chemotherapy.

The rat prostatic adenocarcinoma Nb-Pr-A.I.-3, an androgen-insensitive tumor, was evaluated with the following treatments: cyclophosphamide, cis-platinum, adriamycin, and the following combination therapies: cyclophosphamide and cis-platinum; adriamycin and cis-platinum; adriamycin, cis-platinum, and cyclophosphamide.

Combination chemotherapy in a prostate tumor model: Nb rat prostatic adenocarcinoma model.

This report presents the experience with single and combination chemotherapy in the Noble rat prostatic adenocarcinoma model. The best single agent in treatment of these tumors is cyclophosphamide, the best combination was triple drug therapy cyclophosphamide, cis-platinum, and adriamycin. This report examines the effect of the various chemotherapeutic regimens on tumor volume, number of metastasis, and complete tumor regression.

Heterotransplantation of Nb rat prostatic adenocarcinomas into congenitally athymic nude mice.

Although Nb rat prostatic adenocarcinoma rarely occurs spontaneously, the frequency of occurrences is increased by hormone induction. In this study, the Nb rat prostatic adenocarcinomas, Pr-90 and 13-Pr-12, were heterotransplanted into congenitally athymic (nude) mice for the purpose of evaluating the response of these tumors to chemotherapeutic agents. Adriamycin and methotrexate were evaluated in treating both tumors, and cyclophosphamide and BCNU + 5 FU were evaluated in 13-Pr-12.

Evaluation of nonhormonal cytotoxic chemotherapy in the Nb rat prostate adenocarcinoma: autonomous tumor (18-Pr and 13-Pr).

The Nb rat prostatic adenocarcinomas is an appropriate animal model for the study of cytotoxic chemotherapeutic agents. The autonomous tumor, 18-Pr, was evaluated with single-agent cytotoxic chemotherapy consisting of actinomycin-D, BCNU, cyclophosphamide, and two doses of 5-fluorouracil (5-FU). The effect of these agents was significant (P less than 0.

Evaluation of chemotherapeutic responsiveness in Nb rat prostate cancer model. 5-fluorouracil, methotrexate, cyclophosphamide, and adriamycin.

We elevated four chemotherapeutic agents in 105 male Nb rats with transplanted Nb rat prostatic tumors. Tumor volume and the presence or absence of metastasis were determined at the completion of the experiment and served as indicators of agent effectiveness. 5-Fluorouracil and cyclophosphamide were the most effective agents (P < 0.

Evaluation of nonhormonal cytotoxic chemotherapy in the Nb rat (Pr-90) prostatic carcinoma.

The Nb rat prostate adenocarcinoma occurs spontaneously. The frequency of occurrence is increased by hormone induction. Tumors are classified as autonomous or estrogen or androgen dependent, based on their response to hormone manipulation.

The Nb rat prostatic adenocarcinoma model system.

Nb rat prostatic adenocarcinomas have been successfully transplanted into groups of syngeneic Nb rats, as well as into congenitally athymic (nude) mice, with a high frequency of success. This rate of success is one characteristic of this system that allows for experimentation in vivo in large numbers of animals for statistical considerations such as the following: similarity to human prostatic adenocarcinoma, histopathologic response to appropriate hormonal therapy in the case of androgen-dependent tumors, histochemical characteristics, presence of metastases, presence of acid phosphatase, preliminary data revealing the presence of receptors and autonomous tumor models that are refractory to hormonal manipulation (analogous to patients with prostatic carcinoma no longer sensitive to hormonal manipulation). Additionally, the stability in tumor growth kinetics, as well as the histologic and biochemical parameters, is an important consideration in this tumor model for chemotherapeutic and hormonal studies and the tumor response to such modalities.

Therapeutic manipulation of Nb rat prostatic adenocarcinomas: chemotherapeutic evaluation of autonomous tumors.

Nb rat autonomous prostatic adenocarcinomas were transplanted into several groups of synergeneic Nb rats. Chemotherapy using 5-fluorouracil, methotrexate, Adriamycin, and cyclophosphamide was evaluated. Significance was seen with the use of these agents with varying doses.

The effect of 5-fluorouracil and adriamycin on heterotransplantation of Noble rat prostatic tumors in congenitally athymic (nude) mice.

The Nb rat prostatic adenocarcinoma is a well-characterized, hormonally induced family of tumors that are all readily transplantable into congenitally athymic (nude) mice. Because of this versatile heterotransplantation model, multiple replicate copies of individual tumors can be studied "in rodent." We have extended this by studying the chemotherapeutic response of such tumors and believe that this provides a useful avenue for evaluation of cytotoxic agents.

Comparative patterns of serum immunoglobulin levels in specific-pathogen-free congenitally athymic (nude), hereditarily asplenic (Dh/+), congenitally athymic-asplenic (lasat) and splenectomized athymic mice.

Serial determinations of serum immunoglobulin levels were assessed in congenitally athymic (nude), hereditarily asplenic (Dh/+) and congenitally athymic-asplenic (lasat) mice and the results compared to normal intact littermate controls (nu/+), neonatally splenectomized nu/+ and neonatally splenectomized nude mice. Quantification of Ig levels was accomplished by radial immunodiffusion, for IgM, IgG1, IgG2a, IgG2b and IgA antibody isotypes. Intact spleen and/or thymus function was shown to have marked effects on the age-dependent development of serum IgM, IgG2b and IgA production.

The use of percutaneous nephrostomy in 42 patients.

Percutaneous nephrostomy has been used for the diagnosis and treatment of 42 patients with obstructive uropathy. Bilateral puncture was done in 6 cases and this was the sole means of establishing permanent urinary diversion in 8.

Virilizing adrenal cortical carcinoma with hypertrophy of spermatic tubules in childhood.

A review of adrenal cortical carcinoma in childhood is presented, including endocrinologic aspects. Electron microscopic features are presented, as well as the finding of hypertrophied spermatic tubules. The importance of serial steroidal determinations is stressed as a "tumor marker" that may help in early detection of recurrent disease and possibly increased long-term survival.

The Nb rat: prostatic adenocarcinoma model.

The Noble rat prostatic adenocarcinoma is an animal model which is used to study human prostatic carcinoma. It mimics the human condition in histology, in biochemistry with the production of acid phosphatase, and in tumor growth which is relatively constant. Additionally, it is hormonally dependent and metastasizes.