Confocal laser scanning microscopy study of intercellular events in filopodia using 3-mercaptopropoinc acid capped CdSe/ZnS quantum dots.

Physico-chemical mobility of cells in three dimensions is dependent on the development of filipodia, which is the fundamental instinct for survival and other cellular functions in live cells. Specifically, our present research paper describes the synthesis of 3-Mercaptopropoinc acid (MPA) capped CdSe/ZnS quantum dots (QDs), which are biocompatible and utilized for cellular bioimaging applications. Using the pancreatic cell lines BXCP3 cells, we successfully demonstrated the applicability of MPA-capped QDs for intercellular filopodia imaging.

In Silico Studies on Anti-Stress Compounds of Ethanolic Root Extract of Hemidesmus indicus L.

Background: Alternative medicine is available for those diseases which cannot be treated by conventional medicine. Ayurveda and herbal medicines are important alternative methods in which the treatment is done with extracts of different medicinal plants. This work is concerned with the evaluation of anti-stress bioactive compounds from the ethanolic root extract of Hemidesmus indicus.

First magenetic resonance imaging studies on aluminium maltolate-treated aged New Zealand rabbits: an Alzheimer's animal model.

Background: Alzheimer's disease is a devastative neurodegenerative disorder. To date, there has been no animal model that could unravel the complete disease pathology. Magnetic resonance imaging has played a pivotal role in the quantitative assessment of brain tissue atrophy for a few decades.

Molecular docking and P-glycoprotein inhibitory activity of flavonoids.

Flavonoids are the most common group of phenolic compounds that have anti-carcinogenic properties and are the constituents of fruits, vegetables and plant derived beverages. In the present study, Flavonoids were docked to three-dimensional structure of P-glycoprotein which plays an important role in multi drug resistance. A three-dimensional homology model of human P-glycoprotein was built, based on the crystal structure of the 3G5U (Chain A; Structure of a bacterial multidrug ABC transporter) by using Modeller7v7 software.

Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues.

Alzheimer's disease (AD) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. The extracts of plants and their effect on the amelioration of AD symptoms have been extensively studied. This paper summarizes the mechanisms like acetylcholinesterase (AChE) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of AD symptoms.

Carotenoids and Alzheimer's disease: an insight into therapeutic role of retinoids in animal models.

Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review focuses on the role of carotenoids like retinoic acid (RA), all trans retinoic acid (ATRA), lycopene and β-carotene in prevention of AD symptoms primarily through inhibition of amyloid beta (Aβ) formation, deposition and fibril formation either by reducing the levels of p35 or inhibiting corresponding enzymes.

Expression of bovine (Bos indicus) interleukin-18 in Escherichia coli and its biological activity.

IL-18 modulates immune functions by inducing IFN-γ production and promoting Th1 immune responses. In the present study, we amplified and cloned the sequence (582 bp) encoding full-length bovine IL-18 from PBMC stimulated with PHA. The nucleotide and the deduced amino acid sequence of Bos indicus IL-18 showed an identity of 86-98% compared with IL-18 sequences of other ruminants.

Animal models of Alzheimer's disease: an understanding of pathology and therapeutic avenues.

Alzheimer's disease is a neurodegenerative disorder with unclear etiology for a few decades. Many animal models employed to study the etiology of the disease and test the efficacy of a drug could give limited understanding of these events. Introduction of aluminum salts into aged New Zealand rabbit brain could demonstrate neurofibrillary tangle formation in 1965.

DNA damage and impairment of DNA repair in Alzheimer's disease.

Deoxyribonucleic acid (DNA) damage has been implicated in ageing and neurodegenerative disorders including Alzheimer's disease (AD) for a few decades. Although it is an established finding, yet there are limited studies on DNA damage. In both nucleus and mitochondria, DNA damage is primarily free radical mediated.

Studies on genomic DNA stability in aluminium-maltolate treated aged new zealand rabbit: relevance to the alzheimers animal model.

Background: Alzheimers disease (AD) is a devastative neurodegenerative disorder. Lack of substantial animal model that can unravel molecular underpinnings has been a major lacuna which limited the understanding of the etiology of the disease in turn limiting the employment of potential therapeutic strategies to combat the disease for a few decades. Our studies for the first time provided substantial animal model and tattered the etiology of the disease at a molecular level.

Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum.

Lysyl tRNA synthetases facilitate amino acylation and play a crucial role in the essential cellular process of translation. They are grouped into two distinct classes (class I and class II). Class I lysyl tRNA synthetase is considered as a drug target for syphilis caused by Treponema pallidum.