Discovery and validation of urinary biomarkers for prostate cancer.

Only 30% of patients with elevated serum prostate specific antigen (PSA) levels who undergo prostate biopsy are diagnosed with prostate cancer (PCa). Novel methods are needed to reduce the number of unnecessary biopsies. We report on the identification and validation of a panel of 12 novel biomarkers for prostate cancer (PCaP), using CE coupled MS.

Whole-body hyperthermia in combination with platinum-containing drugs in patients with recurrent ovarian cancer.

Background: Patients with advanced ovarian cancer have an enormous risk of relapse after primary therapy, and the prognosis for these patients remains bleak. Primary and acquired resistance of tumor cells to antineoplastic drugs is a major cause of the limited effectiveness of chemotherapy. The effect of whole-body hyperthermia (WBH) combined with platinum-containing chemotherapy in the treatment of recurrent ovarian cancer was examined in this study.

Posttreatment histology and microcirculation status of osteogenic sarcoma after a neoadjuvant chemo- and radiotherapy in combination with local electromagnetic hyperthermia.

Background: Many biological attributes of tumors (including regional blood flow and microcirculation) can deteriorate the homogeneity of heat distribution and temperature elevation during hyperthermia. We analyzed the connection between the microcirculation status of osteogenic sarcomas and the posttreatment histology after neoadjuvant chemotherapy, irradiation and local hyperthermia.

Patients And Methods: 62 patients with histologically verified osteosarcoma (35 men, 27 women, age 9-53, average 21 years) were enrolled in the retrospective pathohistological study.

Water states in living systems. I. Structural aspects.

Formation and special consequences of water-ordering are studied and discussed. Based on the knowledge of the water states, a special dynamic clustering (called dynamic frustration) is suggested. This can be an essential mechanism for life processes.

[Diagnosis and therapy of malignant testicular neoplasms].

For successful treatment of even advanced testicular tumors an accurate histological classification and clinical staging is necessary. The pathohistomorphological classification can be completed by the so-called tumor markers such as alpha-fetoprotein and beta-humanchoriongonadotropin (beta-HCG). These markers are especially valuable in the follow-up of the patient and in the control of the therapeutical effectivity.

[Immune diagnosis of malignant diseases. X. Value of the electrophoresis mobility test in the diagnosis of broncho-pulmonary diseases].

The frequency of bronchial carcinoma has increased significantly during the last five years. The prognosis depends very much on early diagnosis. With non-invasive methods the diagnosis can often not be certified and the dignity of a tumor can often not be judged preoperatively.

Immunodiagnostics of malignant disease. VI. Electrophoretic mobility test (EMT) in malignant melanoma.

The electrophoretic mobility test (EMT) is an in vitro assay for demonstrating cellular immunity. In the presence of tumor antigens lymphocytes of tumor patients liberate lymphokines, which reduce the charge of indicator particles resulting in a measurable reduction of their eletrophoretic mobility. Lymphocytes of 174 patients were tested by EMT.

[Value of the nitroblue tetrazolium test (NBT) in the clinical diagnosis of bacterial infections].

107 patients and 27 normal individuals underwent the NBT test, as described by PARK et al., in order to ascertain whether it helps to diagnose a bacterial infection. The patients studied consisted of a group with bacterial infections, and a further group suffering from a variety of internal organic diseases of non-bacterial genesis.

[Gliadin-induced migration inhibition of peripheral leucocytes by the agarose-plate technique in patients with coeliac disease (author's transl)].

Sensitisation to gliadin was studied--using a modified leucocyte-migration inhibtion test after Clausen--in patients with coeliac disease (10 patients), ulcerative colitis (9), terminal ileitis (9), bacterial diarrhoea (9), and other gastro-intestinal diseases (14). Only the group of patients with coeliac disease had such specific sensitisation. The migration index, at 0.

[Immunodiagnosis of malignant disease. I. The electrophoresis-mobility test in the diagnosis of bronchial carcinoma (author's transl)].

The electrophoresis-mobility test is an in-vitro method for demonstrating specific sensitized lymphocytes. After incubation with the encephalitogenic factor, lymphocytes from patients with malignant disease liberate a factor which causes a decrease in migration velocity of indicator cells (tanned and sulphosalicyl acid-stabilised sheep erythrocytes = ETS) in an electrical field. 84 patients with pulmonary disease and 20 control persons were examined.

Immunodiagnostics of malignant diseases. II. The electrophoretic mobility test in the diagnosis of gynecological malignancies.

We applied the electrophoretic mobility test (EMT) to 117 patients. 49 patients suffered from gynecological malignant tumors of different types and eleven had a carcinoma in situ. 57 patients served as a control group, 26 of whom were clinically healthy volunteers and 31 had benign gynecological diseases.

Case report: Liver scintigraphy in the follow-up of a patient on cytotoxic therapy.

A 63-year-old male patient with a small cell bronchial carcinoma on cytotoxic therapy was followed up with the use of liver scintigraphy. In the various scintigrams the remission as well as the late reappearance of the liver metastasis was demonstrated. The abnormalities in the liver scintigrams correlated with the biochemical changes throughout the course.

[The leucocyte-migration-inhibition-test in the diagnostic of sarcoidosis (author's transl)].

The positive diagnosis of a sarcoidosis is often difficult since reliable laboratory and radiological parameters are not available. It is therefore often necessary to make the diagnosis with invasive methods. The Kveim skin test has many disadvantages, so that there have been many trials to facilitate the diagnosis by in vitro systems.