Off-label use of biologics in urticarial vasculitis: a European retrospective cohort study.

Objectives: Urticarial vasculitis (UV) is characterized by atypical urticarial lesions and leukocytoclastic vasculitis, sometimes with extracutaneous manifestations. First-line treatment is based on colchicine, hydroxychloroquine, dapsone or low-dose glucocorticoids. In refractory forms, the use of biologics has been anecdotally described as potentially effective.

Assessing the swelling behavior of oil paint in fatty acid methyl esters (FAMEs).

Fatty Acid Methyl Esters (FAMEs) have gained attention as low-impact solvents, offering low toxicity and versatility in applications ranging from biofuels to chemical feedstocks. This study investigates the swelling behavior of naturally-aged zinc white oil paint fragments when exposed to FAMEs with varying chain lengths. Swelling was monitored using a microscopy-based image analysis technique over a 15 minutes period, demonstrating that FAMEs induce low to moderate swelling in oil paints, consistent with prior findings on solvent-paint interactions.

Omalizumab Drug Survival in Chronic Urticaria: A Retrospective Multicentric French Study.

Background: Omalizumab (OMA) dramatically improves disease control and quality of life in patients with chronic urticaria (CU).

Objective: We aimed to evaluate the discontinuation patterns of OMA and their determinants in a cohort of French patients with CU.

Methods: We conducted a retrospective multicenter study in 9 French tertiary referral hospitals.

Discrepancies in the management of acquired cold contact urticaria: Results of a French-speaking urticaria experts questionnaire survey.

Acquired cold contact urticaria (ACU) is a putatively serious condition, because of the risk of anaphylactic shock whenever patients are massively exposed to cold atmosphere/water, raising the question of the prescription of an "emergency kit" with oral antihistamines and epinephrine auto-injector. We performed an online survey to evaluate how French-speaking urticaria experts manage ACU. According to the 2016 consensus recommendations on chronic inducible urticarias, all the participants perform at least 1 of the available provocation tests and 84.

[Development and validation of a questionnaire to assess facial handicap in systemic sclerosis].

Background: Many studies have recorded significant impairment of health-related quality of life in systemic sclerosis patients using validated scales. However, these instruments are not specifically designed for facial signs.

Objectives: To develop and validate a specific questionnaire to assess the burden on patients with facial signs of systemic sclerosis and which we have named "Burden of Face Affected" (BoFA).

Glucocorticoids for acute urticaria: study protocol for a double-blind non-inferiority randomised controlled trial.

Introduction: This study protocol describes a trial designed to investigate whether antihistamine alone in patients with acute urticaria does not increase the 7-day Urticaria Activity Score (UAS7) in comparison with an association of antihistamine and glucocorticoids and reduces short-term relapses and chronic-induced urticaria.

Methods And Analysis: This is a prospective, double-blind, parallel-group, multicentre non-inferiority randomised controlled trial. Two-hundred and forty patients with acute urticaria admitted to emergency department will be randomised in a 1:1 ratio to receive levocetirizine or an association of levocetirizine and prednisone.

Rare complication of antimalarial prophylaxis by doxycycline: drug-related pollakiuria.

We report the case of a French soldier deployed in Chad, who developed disabling pollakiuria after starting antimalarial prophylaxis by doxycycline. This rare secondary effect is not mentioned in reference books.

Collagen fiber orientation pattern, osteon morphology and distribution, and presence of laminar histology do not distinguish torsion from bending in bat and pigeon wing bones.

Bone can adapt to its habitual load history at various levels of its hierarchical structural and material organization. However, it is unclear how strongly a bone's structural characteristics (e.g.

Efficacy and safety of oral alitretinoin as treatment for chronic hand eczema in France: a real-life open-label study.

Background: Chronic hand eczema is an inflammatory dermatosis that results in a significant psychological and socio-economic burden. Alitretinoin (AL) is indicated in adults with severe chronic hand eczema (sCHE) unresponsive to potent topical corticosteroids.

Objectives: To assess AL effectiveness and safety in patients with sCHE under real-life conditions based on a prospective observational study in France (2010-2014).

[What's new in internal medicine?].

What's new in internal medicine will be dedicated to three topics: i) inflammatory myopathies constituting a heterogenous group of diseases whose clinical manifestations, immunological abnormalities, treatment response and outcomes vary widely; ii) alterations of gut microbiota contributing to the occurrence or development of a range of conditions, including autoimmune diseases for which further work is necessary to understand the correlation of dysbiosis with these diseases; iii) the reciprocal relationship between obesity, metabolic syndrome, atherosclerosis and autoimmune diseases. New data concerning systemic sclerosis, cutaneous vasculitis, adult Still's disease, autoantibodies anti DFS70, Epstein Barr virus and autoimmune diseases were also highlighted.