Platelet-neutrophil aggregate formation induces NLRP3 inflammasome activation in vaccine-induced thrombotic thrombocytopenia.

Background: Although rare, vaccine-induced thrombotic thrombocytopenia (VITT) following adenoviral vector COVID-19 vaccination is a concerning and often severe adverse effect of vaccination. The generation of high antiplatelet factor 4 antibody titers promotes the formation of immune complexes capable of activating platelets and neutrophils through FcγRIIa.

Objectives: Given that platelet-leukocyte aggregate formation and inflammasome activation are common features of thromboinflammatory diseases, we aimed to evaluate if these are also features of VITT.

Oral issues and childhood stress in eight-to-ten-year-old schoolchildren: a case-control study.

Objective: The aim of the present study was to investigate whether oral problems, harmful oral habits, and sociodemographic factors are associated with the occurrence of stress in schoolchildren.

Materials And Methods: A case-control study nested within a cross-sectional study was conducted with a sample of 375 schoolchildren eight to ten years of age in the city of Diamantina, Brazil. The case group (with childhood stress) and control group (without childhood stress) were matched for age and sex at a 1:4 ratio (75 cases to 300 controls).

Primary Stability and Fracture Resistance of Zirconia and Titanium Implants: A Paired Comparative In Vitro Study.

Purpose: Compare Neodent Zi® zirconia implants' insertion torque (IT) and removal torque (RT) with Neodent Alvim® titanium. Measure the maximum torque supported by the zirconia implant until its fracture (MT) and the maximum torque sustained by the assembler of this implant (MTA) until its fracture.

Material And Methods: In this in-vitro study twenty four implants were used.

Reliability and validity of cross‑culturally adapted oral health‑related quality‑of‑Life instruments for Brazilian children and adolescents: a systematic review.

Objective: This systematic review aimed to review the reliability and validity of oral health-related quality of life (OHRQoL) questionnaires for Brazilian children and adolescents. Also, the cross-cultural adaptation was evaluated.

Methods: This systematic review is registered in PROSPERO (CRD42022300018) and was performed based on the COSMIN guideline.

Psychometric assessment of oral health-related quality of life questionnaires cross-culturally adapted for use in Brazilian adults - a systematic review.

Objective: This study aimed to review the psychometric properties of oral health-related quality of life (OHRQoL) questionnaires for the Brazilian adult population.

Methods: A systematic review was performed based on the COSMIN guidelines (PROSPERO CRD42022300018). The studies were obtained through electronic searches in the PubMed/MEDLINE, Web of Science, Lilacs, VHL (BIREME), SciELO, and Embase databases.

Patient-reported measures outcomes: modern evaluation of oral health.

Patient reported outcomes have become important, with instruments (patient reported outcomes measures - PROMs) being used to assess treatment success and patient satisfaction. In this editorial, the dental PROM context is presented, and submissions are invited for a special collection from BMC Oral Health entitled 'Patient-reported outcomes in dentistry'.

Counselling treatment versus counselling associated with jaw exercises in patients with disc displacement with reduction-a single-blinded, randomized, controlled clinical trial.

Objective: To compare effectiveness of counselling program versus counselling program plus jaw exercises to reduce pain and click in patients with temporomandibular joint disc displacement with reduction (DDWR).

Materials And Methods: Patients were divided into two groups: instructions for temporomandibular disorders (TMD) plus jaw exercises (test, n = 34), only TMD instructions (control, n = 34). Pain was analyzed by palpation (RDC/TMD).

ICU Admission, Invasive Mechanical Ventilation, and Mortality among Children and Adolescents Hospitalized for COVID-19 in a Private Healthcare System.

Aim: The COVID-19 pandemic devastated healthcare around the world. Data about the COVID-19 outcomes among young people are still scarce. We aim to identify factors associated with the composite outcome among children and adolescents hospitalized due to COVID-19.

Test of the FlashFREEZE unit in tissue samples freezing for biobanking purposes.

Availability of molecularly intact biospecimens is essential in genetic diagnostics to obtain credible results. Integrity of nucleic acids (particularly RNA) may be compromised at various steps of tissue handling, and affected by factors such as time to freeze, freezing technique and storing temperature. At the same time, freezing and storing of the biological material should be feasible and safe for the operator.

Microtensile resistance of an adhesive system modified with chitosan nanoparticles.

Aim: The aim of this study was to evaluate whether 2.5% chitosan applied after dentin acid etching or incorporated into the adhesive system interferes with the microtensile strength of the interface tooth-resin.

Subjects And Methods: Sixty healthy bovine teeth had the incisal thirds and the roots sectioned and were randomly allocated into three groups ( = 60).

Prevalence of Mandibular Third Molars According to the Pell & Gregory and Winter Classifications.

Aim: This study aimed to evaluate the prevalence of mandibular third molar positions according to the Pell & Gregory and Winter classifications, and to verify the association between the two classification methods.

Material And Methods: This cross-sectional study was conducted at dental imaging clinic, from January to March 2019. The inclusion criteria were third molars with complete rhizogenesis and the presence of the mandibular second molar.

Effect of social isolation on oral health status - A systematic review.

Aim: To determine the magnitude of the association between social isolation and oral health in adults.

Materials And Methods: Systematic review based on PRISMA guidelines. Observational studies and clinical trials were obtained by searching the electronic databases of PubMed/MEDLINE, Web of Science, Scopus, Cochrane Library electronic, SciELO, Science Direct and Embase.

Functionalized microchannels as xylem-mimicking environment: Quantifying X. fastidiosa cell adhesion.

Microchannels can be used to simulate xylem vessels and investigate phytopathogen colonization under controlled conditions. In this work, we explore surface functionalization strategies for polydimethylsiloxane and glass microchannels to study microenvironment colonization by Xylella fastidiosa subsp. pauca cells.

Oral health-related quality of life in patients with disc displacement with reduction after counselling treatment versus counselling associated with jaw exercises.

Objective: The aim of this study was to compare the effectiveness of two types of treatment (counselling programme versus counselling programme plus jaw exercises) to improve the quality of life of patients with disc displacement with reduction (DDWR).

Materials And Methods: Patients were divided into two groups. The test group received guidelines for temporomandibular disorders (TMD) plus jaw exercises for DDWR, and the control group received only guidelines for TMD.

Resistance to fracture of intraradicular posts made of biological materials.

Background: The aim was to analyze the fracture resistance of human teeth treated endodontically and restored with posts made of bovine dentin, human dentin, or glass fiber, and to evaluate the fracture pattern.

Methods: Cylindrical posts of 1.5 mm in diameter cemented to the roots of human maxillary canines presented a length of 15 mm, cervical diameter of 5-5.

Frequency and coexistence of KRAS, NRAS, BRAF and PIK3CA mutations and occurrence of MMR deficiency in Danish colorectal cancer patients.

The MAPK signalling genes KRAS, NRAS and BRAF and the PIK3CA gene are routinely investigated for mutations in the diagnostic routine of colorectal cancer. Few studies have reported co-existing mutations in these genes with clinical relevance, while some have been previously regarded as mutually exclusive. We set to investigate the frequency and co-occurrent mutations in these targets, and the occurrence of mismatch repair deficiency (dMMR) in a large cohort of Danish colorectal cancers.

Slave Voyages: Reflections on Data Sculptures.

This pictorial presents the development of a data sculpture, followed by our reflections inspired by Research through Design (RtD) and Dahlstedt's process-based model of artistic creativity. We use the notion of negotiation between concept and material representation to reflect on the ideation, design process, production, and the exhibition of "Slave Voyages" - a set of data sculptures that depicts slave traffic from Africa to the American continent. The work was initially produced as an assignment on physicalization for the Design course at the Federal University of Rio de Janeiro.

Nanoparticles Loaded with a New Thiourea Derivative: Development and Evaluation Against .

Background: Leishmaniasis is a neglected tropical disease caused by protozoa of the genus . Current treatments are restricted to a small number of drugs that display both severe side effects and a potential for parasites to develop resistance. A new -(3,4-methylenedioxyphenyl)-'- (2-phenethyl) thiourea compound (thiourea 1) has shown promising activity against with an IC of 54.

Is there an association between attention deficit hyperactivity disorder in children and adolescents and the occurrence of bruxism? A systematic review and meta-analysis.

Aim of the present systematic review was to evaluate whether children and adolescents with attention-deficit/hyperactivity disorder (ADHD) are at greater chance of developing bruxism compared to individuals without this disorder. Observational studies that evaluated the occurrence of bruxism in children and adolescents with ADHD were included. The quality of the evidence was evaluated using the Grading of Recommendations, Assessment, Development and Evaluation criteria.

Sensitivity and specificity of assessment scales of dentin hypersensitivity - an accuracy study.

The aim of the present study was to compare the sensitivity and specificity of pain scales used to assess dentin hypersensitivity (DH). The preferred scale, and toothbrushing habits of participants were also investigated. This cross-sectional study was conducted with students and employees of a Brazilian Federal University who presented DH.

Clinical and radiographic evaluation of the Periodontium with biologic width invasion.

Background: The biologic width is defined as the coronal dimension to the alveolar bone that is occupied by healthy gingival tissue. The objective of the present study was to correlate radiographic findings of biologic width invasion with the periodontium status.

Methods: It were included 14 patients with restored teeth with biological width invasion, on the proximal sites, observed clinically and radiographically.

Evaluation of the bioaccumulation kinetics of toxic metals in fish (A. brasiliensis) and its application on monitoring of coastal ecosystems.

This study proposes a pro-active approach for evaluations of methylmercury (MeHg), total mercury (THg), arsenic (As), cadmium (Cd) and lead (Pb) in situ bioaccumulation in fish (Atherinella brasiliensis) muscles, using specimens from the external sector of Guanabara Bay as a study case. This approach included an hierarchical sequence: analysis of the pollutants concentrations and their comparison to safety criteria; correlations between specimens concentrations vs length (as a proxy of exposure time); projections of concentrations in key lengths (sexual maturation, asymptotic, length limits for fishing and median of fish population) through polynomial regressions, dose-response analysis (Probit), decreasing curves and incorporation rates (using only three length intervals). The incorporation rates were ascending for MeHg and THg (continued bioaccumulation) and descending for As, Pb and Cd (possible biological dilution).

Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial.

Background: This study aimed to evaluate the efficacy of ozonized water on pain, oedema and trismus after impacted third molar mandibular surgeries when compared to double distilled water. A randomized triple blind trial was conducted.

Methods: Patients with third molars class II-B of Pell-Gregory were included, and surgical extraction was performed.

Systematic review of biological therapy to accelerate orthodontic tooth movement in animals: Translational approach.

Objectives: To systematically review and evaluate what is known regarding contemporary biological therapy capable of accelerating orthodontic tooth movement (OTM) in animal model.

Materials And Methods: MedLine, Scopus, Web of Science and OpenGrey were searched without restrictions until June 2019. Following study retrieval and selection, relevant data was extracted using a standardized table.