Publications by authors named "Douglas Zipes"
Article Synopsis
- The LIVE-LQTS study aimed to investigate whether vigorous exercise increases the risk of ventricular arrhythmias in individuals with congenital long QT syndrome (LQTS) by tracking participants' activity and health events over three years.
- Among 1,413 participants, 52% engaged in vigorous exercise, and the study found similar rates of serious cardiac events (2.6% in vigorous exercisers vs. 2.7% in non-vigorous) suggesting that vigorous exercise may not significantly increase risk for these individuals.
- The results had a hazard ratio of 0.97, indicating that vigorous exercisers experienced similar or potentially lower rates of adverse events than those who did not exercise vigorously, providing insight into safe exercise practices for LQ
Article Synopsis
- The study investigates whether vigorous exercise increases the risk of ventricular arrhythmias and mortality in individuals with hypertrophic cardiomyopathy (HCM).
- Researchers enrolled 1,660 participants aged 8 to 60 with HCM or its genetic markers, categorizing them by their exercise levels (sedentary, moderate, vigorous).
- The primary outcomes included serious events like death and arrhythmias, with findings analyzed by an unbiased committee to evaluate the effects of exercise intensity on these health risks.
Cardiac Sympathectomy and its Enduring Value for the Management of Long QT Syndrome.
JACC Clin Electrophysiol
March 2022
Catheter ablation is an established treatment option for atrial fibrillation (AF), and pulmonary vein isolation (PVI) has become the gold standard in AF ablation. AF recurrence after PVI remains an important clinical problem. Recovery of conduction from the pulmonary veins (PVs) is considered the dominant mechanism for AF recurrence in paroxysmal AF.
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- The US DOJ investigated the usage of implantable cardioverter-defibrillators (ICDs) that didn't meet Medicare criteria, focusing on hospitals that settled versus those that did not.
- The study analyzed data from over 300,000 ICDs at 1809 hospitals from 2007 to 2015 to determine the impact of the DOJ's investigation announcement on compliance with NCD criteria.
- Results showed that settlement hospitals experienced a greater decrease in non-compliance with NCD criteria following the investigation announcement compared to nonsettlement hospitals, particularly in early 2010.
Ablation of Atrial Gangionated Plexi to Treat Symptomatic Sinus Bradycardia.
JACC Clin Electrophysiol
September 2017
Professional society recommendations to decrease sudden cardiac death in athletes, including eligibility requirements with disqualification for athletes with diagnosed disease as well as preparticipation screening and emergency preparedness, were updated in 2015. The update includes new sections on aortic disease, channelopathies, and sickle cell trait, as well as a change in format from the previous binary yes/no format to the more nuanced and contemporary "class and level of evidence" format. Eighty-four of the 246 recommendations now carry Class II designation-"reasonable," or "may be considered.
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- The autonomic nervous system is essential for normal heart function and significantly influences various cardiovascular diseases.
- Advances in neuroscience are highlighting the potential of new cardiovascular treatments.
- This White Paper examines human cardiac neuroanatomy, the impact of diseases, testing methods, risk evaluation, and neuromodulation strategies for improving heart health.
Objectives: The primary objective of the study was a change in left ventricular end-systolic volume index (LVESVi) from baseline to 6 months of spinal cord stimulation (SCS) therapy in the treatment arm compared to the control arm as measured by echocardiography. Secondary objectives were changes in peak oxygen uptake and N-terminal pro-B-type natriuretic peptide (NT-proBNP) between the treatment arm and control arm from baseline through 6 months.
Background: Abnormal neurohormonal activation is often responsible for progression of heart failure (HF).