Publications by authors named "Douglas W Barrows"
Food intake and body weight are tightly regulated by neurons within specific brain regions, including the brainstem, where acute activation of dorsal raphe nucleus (DRN) glutamatergic neurons expressing the glutamate transporter Vglut3 (DRN) drive a robust suppression of food intake and enhance locomotion. Activating Vglut3 neurons in DRN suppresses food intake and increases locomotion, suggesting that modulating the activity of these neurons might alter body weight. Here, we show that DRN neurons project to the lateral hypothalamus (LHA), a canonical feeding center that also reduces food intake.
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- Menin interacts with oncogenic MLL1-fusion proteins, and small molecules targeting this interaction are being tested in clinical trials to treat leukemia.
- Research has uncovered a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that influences how leukemia cells respond to Menin-MLL inhibitors.
- Activating tumor-suppressive genes through CDK4/6 inhibitors can overcome treatment resistance in leukemia cells resistant to Menin inhibitors, highlighting new therapeutic strategies.