Chronic ethanol reduces nicotine-induced dopamine release in PC12 cells.

Background: There is a high correlation between alcohol and nicotine use; that is, alcohol use is associated with high levels of smoking. One important aspect of nicotine addiction appears to be the activation of nicotinic acetylcholine receptors on dopaminergic neurons projecting from the ventral tegmental area to the nucleus accumbens. The release of dopamine from these neurons is thought to mediate, at least in part, the reward of nicotine consumption.