Publications by authors named "Douglas M Altrogge"
Noninvasive polarimetric-based glucose monitoring: an in vivo study.
J Diabetes Sci Technol
March 2011
Background: Since 1990, there has been significant research devoted toward development of a noninvasive physiological glucose sensor. In this article, we report on the use of optical polarimetry for the noninvasive measurement of physiological glucose concentration in the anterior chamber of the eye of New Zealand white (NZW) rabbits.
Method: Measurements were acquired using a custom-designed laser-based optical polarimetry system in a total of seven NZW rabbits anesthetized using an isoflurane-only anesthesia protocol.
Article Synopsis
- Hepatocellular vacuolation is tricky for doctors because different stuff can build up in liver cells and look similar under a microscope.
- Some common ways to tell them apart are not very sensitive and need special types of tissue samples.
- A new method using specific stains can help doctors see the differences more easily in liver tissue from rats and works better than older methods.
The antidiabetic agent troglitazone was given to groups of 4 cynomolgus monkeys per sex at 300, 600, or 1200 mg/kg daily by gavage for 52 weeks. A group of 4 monkeys per sex received vehicle alone and served as controls. Emesis and soft stool or diarrhea occurred sporadically in all troglitazone-treated groups, but did not compromise animal health.
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