Publications by authors named "Douglas L Richards"

Article Synopsis
  • 28 adults participated in a study to examine the effects of ketone ester (KE) supplementation on exercise performance, consuming either low (KE-LO) or high (KE-HI) doses or a placebo before exercise.
  • The results showed that KE ingestion significantly increased levels of ß-hydroxybutyrate, a key ketone body, but did not improve exercise economy or efficiency during submaximal cycling compared to the placebo.
  • Interestingly, participants had higher heart rate and ventilation with KE intake, but the peak power output was lower in the high dose group (KE-HI) compared to both the low dose and placebo, despite no changes in overall oxygen uptake (V̇O2peak).
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Sprint interval training (SIT) increases peak oxygen uptake (V̇O) but the mechanistic basis is unclear. We have reported that 12 wk of SIT increased V̇O and peak cardiac output (Q̇) and the changes in these variables were correlated. An exploratory analysis suggested that Q̇ increased in males but not females.

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Vigorous intermittent exercise can improve indices of glycemia in the 24 h postexercise period in apparently healthy individuals. We examined the effect of a single session of bodyweight exercise (BWE) on glycemic responses using continuous glucose monitoring (CGM) under controlled dietary conditions. Healthy inactive adults (n = 27; 8 males, 19 females; age: 23 ± 3 years) completed 2 virtually supervised trials spaced ~ 1 week apart in a randomized, crossover manner.

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Article Synopsis
  • Acute ketone monoester (KE) supplementation may affect exercise performance, particularly in cycling, though results are inconsistent due to various factors like dose and athlete experience.
  • A study with 23 trained cyclists tested whether KE ingestion affected power output in a 20-minute cycling time trial compared to a placebo, with a significant increase in blood ketones after KE.
  • Results showed that mean power output was actually 2.4% lower after KE supplementation compared to the placebo, indicating that KE may impair performance under certain conditions.
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Article Synopsis
  • The study investigated how ingestion of ketogenic esters (KE) affects cardiac output (Q˙) during exercise and whether bicarbonate can counteract blood acidosis caused by KE intake.
  • Conducted with 15 endurance-trained individuals, the research evaluated blood ketone levels, pH, heart rate (HR), and exercise capacity in three conditions: a control (CON), KE alone, and KE with bicarbonate (KE + BIC).
  • Findings showed that while KE raised heart rate and ketone levels, it did not enhance cardiac output or peak workload during exercise, regardless of blood pH levels.
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Purpose: This study aimed to compare Q˙peak elicited by a constant load protocol ( Q˙CL ) and an incremental step protocol ( Q˙step ).

Methods: A noninferiority randomized crossover trial was used to compare Q˙peak between protocols using a noninferiority margin of 0.5 L·min -1 .

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Introduction: Sprint interval training (SIT), characterized by brief bouts of 'supramaximal' exercise interspersed with recovery periods, increases peak oxygen uptake ([Formula: see text]) despite a low total exercise volume. Per the Fick principle, increased [Formula: see text] is attributable to increased peak cardiac output ([Formula: see text]) and/or peak arterio-venous oxygen difference (a-vO). There are limited and equivocal data regarding the physiological basis for SIT-induced increases in [Formula: see text], with most studies lasting ≤ 6 weeks.

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There is growing interest in the effect of exogenous ketone body supplementation on exercise responses and performance. The limited studies to date have yielded equivocal data, likely due in part to differences in dosing strategy, increase in blood ketones, and participant training status. Using a randomized, double-blind, counterbalanced design, we examined the effect of ingesting a ketone monoester (KE) supplement (600 mg/kg body mass) or flavour-matched placebo in endurance-trained adults ( = 10 males, = 9 females; O = 57 ± 8 mL/kg/min).

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