Publications by authors named "Douglas L Hatch"

Article Synopsis
  • Brazil's MMR vaccination campaign in August 2004 reported unusually high rates of hypersensitivity-type adverse events (HAEs) among vaccinated children.
  • Analysis revealed that HAEs were significantly more prevalent with a specific manufacturer’s vaccine (15.2/100,000 doses) compared to others (1.2 and 0.6/100,000 doses).
  • The study concluded that while HAEs were frequent, they were not associated with a history of food or drug allergies, emphasizing the need for effective vaccine safety surveillance.
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We conducted an epidemiologic investigation of an outbreak of ocular disease among children to determine whether the disease was linked to Emmonsia sp., a rarely-reported fungus and an agent of adiaspiromycosis. Using an unmatched case-control study design, we compared case-patients with asymptomatic controls randomly selected from the population.

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Air pollution is a major public health problem in the Amazon forest and in large Brazilian cities. During September of 2005, high concentrations of smoke from biomass burning were observed in the city of Rio Branco. An ecological study was conducted to evaluate the relationship between daily concentrations of particulate matter < 2.

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Objective: An epidemiological investigation was conducted to determine risk factors for adverse reactions among patients in hospitals and the possibility of extrinsic or intrinsic contamination of intravenous solutions.

Design: A retrospective cohort study was conducted to identify solutions associated with adverse reactions. Implicated lots were cultured for bacteria, and endotoxin concentrations were measured.

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In the last 5 years, Brazil has accounted for approximately 70% of reported dengue fever cases in the Americas. We analyzed trends of dengue and dengue hemorrhagic fever (DHF) from the early 1980s to 2002 by using surveillance data from the Brazilian Ministry of Health. Two distinct epidemiologic patterns for dengue were observed: localized epidemics (1986-1993), and endemic and epidemic virus circulation countrywide (1994-2002).

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