Using Small Samples to Evaluate Normative Reference Ranges for Retinal Imaging Measures.

Significance: Retinal nerve fiber layer (RNFL) deviation maps often incorrectly score healthy eyes as having wedge defects. This study shows how to identify such problems early in the development of normative databases.

Purpose: After reference values are embedded in devices, clinicians and researchers often learn about issues that cause false-positive rates in healthy eyes.

Using perimetric data to estimate ganglion cell loss for detecting progression of glaucoma: a comparison of models.

Purpose: Models relating perimetric sensitivities to ganglion cell numbers have been proposed for combining structural and functional measures from patients with glaucoma. Here we compared seven models for ability to differentiate progressing and stable patients, testing the hypothesis that the model incorporating local spatial scale would have the best performance.

Methods: The models were compared for the United Kingdom Glaucoma Treatment Study (UKGTS) data for the right eyes of 489 patients recently diagnosed with glaucoma.

Contrast sensitivity perimetry data from adults free of eye disease.

This data article contains data referenced in "Individual Differences in the Shape of the Nasal Visual Field" [1]. The data were gathered from volunteers free of eye disease ages 21-85 who were tested with Contrast Sensitivity Perimetry (CSP), which uses a stimulus resistant to effects of defocus and reduced retinal illumination. Some subjects were tested only once or a few times, and others were part of a longitudinal cohort with as many as 10 tests.

Individual differences in the shape of the nasal visual field.

Between-subject differences in the shape of the nasal visual field were assessed for 103 volunteers 21-85years of age and free of visual disorder. Perimetry was conducted with a stimulus for which contrast sensitivity is minimally affected by peripheral defocus and decreased retinal illumination. One eye each was tested for 103 volunteers free of eye disease in a multi-center prospective longitudinal study.

Assessing assumptions of a combined structure-function index.

Purpose: Medeiros et al. developed a combined structure-function index for glaucoma by combining two ganglion cell models developed by Harwerth et al. The current study assessed assumptions of the Medeiros combined structure-function index by evaluating whether the two Harwerth models gave similar distributions of ganglion cells in an independent dataset.

Choice of Stimulus Range and Size Can Reduce Test-Retest Variability in Glaucomatous Visual Field Defects.

Purpose: To develop guidelines for engineering perimetric stimuli to reduce test-retest variability in glaucomatous defects.

Methods: Perimetric testing was performed on one eye for 62 patients with glaucoma and 41 age-similar controls on size III and frequency-doubling perimetry and three custom tests with Gaussian blob and Gabor sinusoid stimuli. Stimulus range was controlled by values for ceiling (maximum sensitivity) and floor (minimum sensitivity).

Contrast sensitivity perimetry and clinical measures of glaucomatous damage.

Purpose: To compare conventional structural and functional measures of glaucomatous damage with a new functional measure-contrast sensitivity perimetry (CSP-2).

Methods: One eye each was tested for 51 patients with glaucoma and 62 age-similar control subjects using CSP-2, size III 24-2 conventional automated perimetry (CAP), 24-2 frequency-doubling perimetry (FDP), and retinal nerve fiber layer (RNFL) thickness. For superior temporal (ST) and inferior temporal (IT) optic disc sectors, defect depth was computed as amount below mean normal, in log units.

Assessing spatial and temporal properties of perimetric stimuli for resistance to clinical variations in retinal illumination.

Purpose: To develop perimetric stimuli for which sensitivities are more resistant to reduced retinal illumination than current clinical perimeters.

Methods: Fifty-four people free of eye disease were dilated and tested monocularly. For each test, retinal illumination was attenuated with neutral density (ND) filters, and a standard adaptation model was fit to derive mean and SEM for the adaptation parameter (NDhalf).

Blur-resistant perimetric stimuli.

Purpose: To develop perimetric stimuli that are resistant to the effects of peripheral defocus.

Methods: One eye each was tested on subjects free of eye disease. Experiment 1 assessed spatial frequency, testing 12 subjects at eccentricities from 2 to 7 degrees using blur levels from 0 to 3 diopters (D) for two (Gabor) stimuli (spatial SD, 0.