Publications by authors named "Douglas F Sales-Medina"

Article Synopsis
  • Loxosceles spp., commonly known as brown spiders, are found in temperate and tropical regions globally, posing a public health risk, particularly in Brazil where incidents of loxoscelism are increasing.
  • The review covers the classification, distribution, and ecological roles of these spiders, along with detailed information on the venom's molecular and biochemical properties.
  • It highlights L. similis, a specific species prevalent in Southeastern Brazil, underscoring its growing significance as a medically important spider in that area.
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Background: The hyaluronidase enzyme is generally known as a spreading factor in animal venoms. Although its activity has been demonstrated in several organisms, a deeper knowledge about hyaluronidase and the venom spreading process from the bite/sting site until its elimination from the victim's body is still in need. Herein, we further pursued the goal of demonstrating the effects of inhibition of T.

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Article Synopsis
  • Scorpion stings from Tityus serrulatus venom can lead to severe cardiac issues, contributing significantly to mortality among victims.
  • The study describes a newly identified toxin called CPP-Ts, which increases calcium release in heart cells, enhancing their contraction frequency.
  • Additionally, CPP-Ts shows potential for use in drug delivery targeting cancer cell nuclei, highlighting a new subfamily of calcium-active toxins and their biotechnological applications.
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