Publications by authors named "Douglas E Cannie"
Article Synopsis
- * The study examined the effects of tafamidis on tissue factor (TF) expression and activity in human aortic endothelial cells (HAECs), revealing that tafamidis significantly reduces TF levels when induced by inflammatory signals.
- * This reduction in TF activity suggests that tafamidis may help lower the risk of blood clots (thromboembolic complications) in patients with ATTR cardiomyopathy, providing insights into its potential benefits beyond just stabilizing TTR.
Background And Aims: Emery-Dreifuss muscular dystrophy (EDMD) is caused by variants in EMD (EDMD1) and LMNA (EDMD2). Cardiac conduction defects and atrial arrhythmia are common to both, but LMNA variants also cause end-stage heart failure (ESHF) and malignant ventricular arrhythmia (MVA). This study aimed to better characterize the cardiac complications of EMD variants.
View Article and Find Full Text PDFBackground: Variants in are reported in 2% to 6% of familial cases of dilated cardiomyopathy and may be associated with fatal ventricular arrhythmia and rapid heart failure progression. We sought to determine the risk of adverse events in variant carriers and the impact of sex on outcomes.
Methods: Consecutive probands and relatives carrying variants were retrospectively recruited from 12 cardiomyopathy units.
Current diagnostic strategies fail to illuminate the presence of rare disease in the heart failure population. One-third of heart failure patients are categorised as suffering an idiopathic dilated cardiomyopathy, while others are labelled only as heart failure with preserved ejection fraction. Those affected frequently suffer from delays in diagnosis, which can have a significant impact on quality of life and prognosis.
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