Publications by authors named "Douglas Charney"

Article Synopsis
  • HIV-1-associated nephropathy (HIVAN) involves changes in kidney cells, specifically the growth of glomerular and tubular epithelial cells, influenced by epithelial mesenchymal transdifferentiation (EMT).
  • Researchers used mouse models to study these changes, finding that certain kidney cells (PGCs and PTCs) showed characteristics of myofibroblasts and that EMT was marked by reduced E-cadherin expression.
  • Blocking the AT1 receptor with telmisartan in Tg26 mice led to a significant decrease in proliferation and EMT marker expression, suggesting that targeting this pathway may help manage HIVAN.
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Background: Previous studies have examined the spectrum of diseases identified with a kidney biopsy and the complications of the procedure. However, few studies have examined the utility of the test to clarify the diagnosis and guide treatment of pediatric patients. This retrospective, single-center chart review was performed to test the hypothesis that at least 80% of native kidney biopsies provide clinically valuable information that rationally guides diagnosis and patient management.

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IgA nephropathy (IgAN) is a common glomerular disease whose etiology is unknown. Previous studies have described the clinical and laboratory features but none have specifically compared patients during different time periods. This 20 year retrospective study was performed to assess trends in the severity of IgAN from 1989-2008.

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Background: Nonalcoholic fatty liver disease (NAFLD) has been consistently associated with obesity and insulin resistance. Nonalcoholic steatohepatitis (NASH) is a histological entity within NAFLD that can progress to cirrhosis. The exact prevalence of NASH in severe obesity is unknown.

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Objective: The purpose of this study was to review the imaging features of mucocelelike breast lesions, correlate the mammographic and pathologic findings, and determine recommendations for management.

Conclusion: Mucocelelike lesions are more common than previously reported and are likely to exhibit indeterminate calcifications on mammography. Diagnosis is most often made with Mammotome biopsy.

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