Publications by authors named "Douglas B Brown"
Background And Objectives: Some reports have suggested that 1.5-millisecond pulse-duration pulsed-dye lasers (PDLs) may have increased efficacy in treating port-wine stains (PWSs) as compared to previous generation lasers. We study the efficacy of the 1.
View Article and Find Full Text PDFObjective: The objective of this study was to assess the safety and efficacy of a 585 nm flashlamp pulsed-dye laser for the nonablative treatment of facial rhytides.
Methods: A multicenter prospective randomized controlled study on 58 volunteers was performed. A split-face approach was adopted, with one periorbital region acting as a control and the other receiving either one or two treatments.
Background: Many light- and laser-based systems are used to reduce cutaneous wrinkles, and some have been shown to stimulate dermal collagen production. Using the ThermaCool TC radiofrequency device to treat bovine tendon and human abdominal skin, we documented the cutaneous effects of a radiofrequency-based system for nonablative treatment.
Observations: Electron microscopy of bovine tendon treated at varied heat and cooling settings revealed collagen fibrils with increased diameter and loss of distinct borders as deep as 6 mm.
Background: Ultraviolet (UV) radiation damages skin through a variety of mechanisms, including the generation of free radicals. Gluconolactone is a polyhydroxy acid (PHA) that is capable of chelating metals and may also function by scavenging free radicals, thereby protecting skin from some of the damaging effects of UV radiation.
Objective: This study measured the ability of gluconolactone to protect against UV radiation-induced damage.