Publications by authors named "Douglas Affonso Formolo"
A sedentary lifestyle is now known as a critical risk factor for accelerated aging-related neurodegenerative disorders. In contract, having regular physical exercise has opposite effects. Clinical findings have suggested that physical exercise can promote brain plasticity, particularly the hippocampus and the prefrontal cortex, that are important for learning and memory and mood regulations.
View Article and Find Full Text PDFResearch suggests that maternal exercise in pregnancy may have beneficial effects on the brain function of offspring. This study sought to determine if voluntary wheel running during pregnancy improves depression-like behavior, temporal order memory, and hippocampal neurogenesis in both female and male offspring mice. Pregnant mice were allowed to run voluntarily by introducing running wheels into the housing cages throughout the gestational period.
View Article and Find Full Text PDFDepression is the most devastating mental disorder and one of the leading contributors to the global medical burden. Current antidepressant prescriptions present drawbacks, including treatment resistance, delayed onset of treatment response, and side effects. The rapid and long-lasting antidepressant effect of ketamine has brought hope to treatment-resistant major depressive disorder patients.
View Article and Find Full Text PDFAmygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
Mol Psychiatry
March 2020
Article Synopsis
- Fear is a conscious response to threats that triggers stress reactions, and in some patients with mesial temporal lobe epilepsy (MTLE-HS), this can result in seizures accompanied by fear, known as ictal fear (IF).
- The study investigated the levels of the GluA1 subunit in the amygdala and specific phosphorylation states in the anterior hippocampus of MTLE-HS patients and found significant differences between those with and without IF.
- Lower levels of GluA1 in the amygdala and phosphorylated GluA1 in the anterior hippocampus were identified as potential biomarkers for predicting the presence of ictal fear, achieving an overall accuracy of 89.3%.
(1) Objectives: Epilepsy disorder is likely to increase with aging, leading to an increased incidence of comorbidities and mortality. In spite of that, there is a lack of information regarding this issue and little knowledge of cognitive and emotional responses in aging subjects following epileptogenesis. We investigated whether and how aging distress epilepsy-related behavioral and biochemical outcomes are associated with cognition and emotion.
View Article and Find Full Text PDFUnlabelled: Cognitive impairment is inherent to the ageing process. Several studies suggest that patients with late-life schizophrenia have more marked cognitive impairment.
Objective: The aim of this study was to compare the cognitive performance of elderly institutionalized patients with schizophrenia and institutionalized elderly control patients without neurological or psychiatric diseases, matched for age, educational level and institutionalization time.