Civamide cream 0.075% in patients with osteoarthritis of the knee: a 12-week randomized controlled clinical trial with a longterm extension.

Objective: To evaluate the safety and efficacy of civamide cream 0.075% for the treatment of osteoarthritis (OA) of the knee.

Methods: We conducted a 12-week, multicenter, randomized, double-blind study with a 52-week open-label extension.