Publications by authors named "Dou-Dou Hu"
MOF-based photoelectrocatalysis (PEC) using CO as an electron donor offers a green, clean, and extensible way to make hydrocarbon fuels under more tolerant conditions. Herein, basic principles of PEC reduction of CO and the preparation methods and characterization techniques of MOF-based materials are summarized. Furthermore, three applications of MOFs for improving the photoelectrocatalytic performance of CO reduction are described: (i) as photoelectrode alone; (ii) as a co-catalyst of semiconductor photoelectrode or as a substrate for loading dyes, quantum dots, and other co-catalysts; (iii) as one of the components of heterojunction structure.
View Article and Find Full Text PDFBackground Biliary obstruction leads to an increase in biliary pressure within the biliary system, which induces the morphologic adaptation of the biliary tree. Purpose To observe and to quantify the morphologic characteristics of the adaptation in a bile duct ligation rat model and verify it in patients with biliary atresia in a three-dimensional (3D) manner using x-ray phase-contrast CT. Materials and Methods A bile duct ligation model was induced in 40 male Sprague-Dawley rats, which were divided into five groups: the control group (no ligation) and groups 2, 4, 6, and 8 weeks after bile duct ligation (eight animals in each group).
View Article and Find Full Text PDFTransforming growth factor-beta 1 (TGF-β1) plays a central role in hepatic progenitor cells- (HPCs-) mediated liver repair and fibrosis. However, different effects of TGF-β1 on progenitor cells have not been described. In this study, both in vitro (HPCs cocultured with hepatic stellate cells (HSCs) in transwells) and in vivo (CCl4-injured liver fibrosis rat) systems were used to evaluate the impacts.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze how angiogenesis, indicated by microvessel density (MVD), relates to portal pressure in a rat model of cirrhosis induced by carbon tetrachloride (CCl4).
- Using a catheter, the researchers continuously measured portal pressure while assessing fibrosis and MVD via image analysis; they found that a significant percentage of rats exhibited high portal pressure, associated with increased MVD and fibrosis.
- MVD showed a strong correlation with portal pressure, particularly in cases of significant hypertension, suggesting it could serve as a reliable indicator for assessing portal hypertension in liver disease patients.
Article Synopsis
- The study utilizes diffraction enhanced imaging (DEI), an advanced X-ray technique, to analyze changes in liver blood vessel structure during conditions like fibrosis and cirrhosis, ultimately assessing its regression.
- Twenty-four rats were used to observe these changes, with results indicating significant increases in vascular density and decreases in intercapillary distance during fibrosis and cirrhosis, compared to healthy controls.
- The findings highlight that while some vascular characteristics improve during the regression phase, cirrhosis does not completely reverse, indicating a complex relationship between angiogenesis and liver disease progression.