Publications by authors named "Dou-Dou Hao"
[Study on the Experimental Methodology of Plasma Clot Retraction].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2024
Article Synopsis
- The study aimed to identify factors that influence plasma clot retraction and improve the experimental methods for analyzing this process, focusing on platelet function regulation and drug effects.
- Researchers experimented with varying concentrations of thrombin, calcium ions, and platelets to refine a detection system for plasma clot retraction, ensuring its reliability by testing various signaling pathway inhibitors.
- Results indicated that using platelet rich plasma with specific thrombin and calcium concentrations led to significant plasma clot retraction, and confirmed that certain inhibitors could notably affect this retraction process.
[Potentiating effect and mechanism of extract of Jingfang Granules on activation of macrophages].
Zhongguo Zhong Yao Za Zhi
May 2023
This study aimed to explore the potentiating effect and mechanism of the extract of Jingfang Granules(JFG) on the activation of macrophages. The RAW264.7 cells were treated with JFG extract and then stimulated by multiple agents.
View Article and Find Full Text PDFGut microbiota profiling revealed the regulating effects of salidroside on iron metabolism in diabetic mice.
Front Endocrinol (Lausanne)
October 2022
Background: Diabetes is a common metabolic disease that is associated with gut microbiota dysbiosis and iron metabolism. Salidroside (SAL) is the main ingredient of the traditional Chinese herb Rhodiola, previous studies have shown that SAL could reshape the gut microbiota and limit iron accumulation. Therefore, it is possible that SAL can act as an alternative therapy for diabetes, and its underlying mechanism is worth exploring.
View Article and Find Full Text PDFKey regulatory genes and signaling pathways involved in islet culture: a bioinformatic analysis.
Int J Clin Exp Pathol
February 2021
Type 1 diabetes (T1D) is characterized by non-ideal mass and low survival rate of islets. Therefore, it is necessary to find intrinsic factors that prolong the survival of islets. This study aimed to track out hub genes and pathways in the process of islet culture by bioinformatic analysis.
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