Efficacy, safety and cost-effectiveness of obinutuzumab in patients with follicular lymphoma: a rapid review.

Background: Obinutuzumab was approved in China in June 2021 used in combination with chemotherapy (followed by obinutuzumab maintenance) for the treatment of adult patients with previously untreated stage II bulky, III, or IV follicular lymphoma (FL). The clinical application of obinutuzumab has recently begun in China, but there is a lack of evidence to determine under which circumstances it should be considered the treatment of choice. A comprehensive assessment is necessary to evaluate the efficacy, safety, and cost-effectiveness of obinutuzumab in adult patients with FL.

GSTA2 overexpression alleviates bis (2-ethylhexyl) phthalate (DEHP)-induced male reproductive disorders by inhibiting oxidative stress-mediated cell apoptosis via the activated PI3K/AKT signaling pathway.

Male reproductive disorders are responsible for approximately 50% of infertility cases. Bis (2-ethylhexyl) phthalate (DEHP) is a common environmental pollutant known for its reproductive toxicity. Oxidative stress is a key mechanism in response to DEHP exposure.

Revealing the Limitations of the Thermocapacitive Cycle.

While thermoelectric conversion by a thermocapacitive cycle has been considered a promising green technology for low-grade heat recovery, our study finds that its practical feasibility is overestimated. During thermal charging, the coexistence and dynamic competition between thermal-induced voltage rise and self-discharge lead to the limitations of the thermocapacitive cycle. Therefore, the operational conditions in the charge-heat-discharge steps seriously restrict the thermal charging performance.

[Predictive value of plasma heparin-binding protein combined with albumin for 28-day mortality in patients with sepsis].

Objective: To evaluate the predictive value of plasma heparin-binding protein (HBP) combined with albumin (Alb) for predicting 28-day mortality in patients with sepsis.

Methods: The clinical data of patients with sepsis admitted to the emergency intensive care unit (EICU) of the People's Hospital of Shenzhen Baoan District from March 2020 to March 2024 were retrospectively analyzed. The study began at the time of the first diagnosis of sepsis upon EICU admission and ended upon patient death or at 28 days.

Artificial intelligence assisted real-time recognition of intra-abdominal metastasis during laparoscopic gastric cancer surgery.

Laparoscopic exploration (LE) is crucial for diagnosing intra-abdominal metastasis (IAM) in advanced gastric cancer (GC). However, overlooking single, tiny, and occult IAM lesions during LE can severely affect the treatment and prognosis due to surgeons' visual misinterpretations. To address this, we developed the artificial intelligence laparoscopic exploration system (AiLES) to recognize IAM lesions with various metastatic extents and locations.

Enhanced toughness of poly(lactic acid) and poly(butylene adipate-co-terephthalate) blends by incorporating an ADR chain-extending agent and a bio-resourced plasticizer.

Over the past decades, emerging bioplastics have attracted much interest from the scientific and industrial communities because of public concerns about environmental problems and sustainable development. In this study, poly(lactic acid) (PLA) was toughened by ductile biodegradable poly(butylene adipate-co-terephthalate) (PBAT) and biosourced plasticizer epoxidized linseed oil (ELO), and a chain-extending agent (CEA) was added to promote the compatibility and toughness of the bio-blends. It was shown that "in situ" grafted polymers were created in the bio-blends with the aid of CEA, greatly enhancing the compatibility and ductility of the compatibilized blends.

Efficacy of preoperative prophylactic application of betamethasone on postoperative nausea and vomiting in patients undergoing total knee arthroplasty: a prospective randomized controlled trial.

Background: The demand for total knee arthroplasty (TKA) is increasing, yet postoperative nausea and vomiting (PONV) significantly hinder patient recovery. Preoperative prophylactic administration of glucocorticoids can alleviate PONV, with betamethasone showing promising results in breast and cardiac surgeries. However, its efficacy in TKA patients remains unclear.

Tough and Stretchable Zwitterionic Eutectogels via Copolymerization-Induced Phase Separation in a Targeted Deep Eutectic Solvent.

Deep eutectic solvent (DES)-based eutectogels show significant promise for flexible sensors due to their high ionic conductivity, non-volatility, biocompatibility, and cost-effectiveness. However, achieving tough and stretchable eutectogels is challenging, as the highly polar DES tends to screen noncovalent bonds, such as hydrogen and ionic bonds, between polymer chains, limiting their mechanical strength. In this work, this issue is addressed by leveraging the limited solubility of zwitterionic polymers in a specific DES to induce phase separation, promoting dipole-dipole interactions between polymer chains.

High Prevalence of 5'UTR Mutations in Anaplastic Thyroid Cancer.

Anaplastic thyroid cancer (ATC) is a rare but one of the most lethal types of human cancer. Although increasing evidence demonstrated that ATC tumors had a high mutation burden, little is known about the aberrancy of the noncoding genome of ATC except the well-investigated () promoter mutations. The mutational statuses of 5' untranslated region (5'UTR), intron 6, and promoters, as well as the promoter and mutations were determined using Sanger sequencing in 28 patients with ATC (19 women and 9 men) with a median (interquartile range) age of 64 (55-71) years, 14 thyroid cancer cell lines and a normal thyroid cell line.

Metastasis-associated lung adenocarcinoma transcript 1 overexpression in testis contributes to idiopathic non-obstructive azoospermia via repressing ETS variant transcription factor 5.

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), is a long non-coding RNA localized in the cell nucleus, known for its multifunctional roles, including potential involvement in spermatogenesis. This study investigates the mechanism by which MALAT1 dysregulation contributes to the pathogenesis of idiopathic non-obstructive azoospermia (iNOA). We analyzed MALAT1 levels in two gene expression profiling datasets comprising patients with obstructive azoospermia (OA) who have normal spermatogenesis and 13 patients with iNOA.

Assessment of and methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China.

Objective: This study aimed to evaluate the clinical utility of methylation (CISCER) test in triaging high-risk human papillomavirus (hrHPV)-positive women.

Methods: We enrolled women who underwent opportunistic screening at Cervical Disease outpatient clinics of Xuzhou Maternity and Child Health Hospital, and Yueyang Central Hospital from December 2022 to May 2024. The effectiveness of CISCER and cytology tests in triaging hrHPV+ patients was analyzed.

Extending visual range of bacteria with upconversion nanoparticles and constructing NIR-responsive bio-microrobots.

The motility of bacteria is crucial for navigating competitive environments and is closely linked to physiological activities essential for their survival, such as biofilm development. Precise regulation of bacterial motility enhances our understanding of these complex processes. While optogenetic tools have been used to control and investigate bacterial motility, the excitation light in most existing systems are limited to the visible light spectrum.

Virtual Reality-based Infrared Pupillometry (VIP) for long COVID.

Objective: To evaluate the use of virtual reality-based infrared pupillometry (VIP) to detect individuals suffering long COVID.

Design: Prospective, case-control cross-sectional study.

Participants: Participants aged 20-60 were recruited from a community eye screening programme.

Synthesis of 2MP-CuNPs Fluorescent Probes and Their Application in Tetracycline Detection.

A fluorescent probe composed of 2-mercaptopyridine-copper nanoparticles (2MP-CuNPs) was synthesized through a hydrothermal method utilizing CuCl and 2-mercaptopyridine (2MP). The experimental results indicate that the 2MP-CuNPs probe exhibited an excellent fluorescence emission peak at 525 nm with an excitation wavelength of 200 nm. Furthermore, this emission peak was accompanied by a substantial Stokes shift of 325 nm, which effectively minimized the overlap between the excitation and emission spectra, thereby enhancing detection sensitivity.

UC-NeRF: Uncertainty-aware Conditional Neural Radiance Fields from Endoscopic Sparse Views.

Visualizing surgical scenes is crucial for revealing internal anatomical structures during minimally invasive procedures. Novel View Synthesis is a vital technique that offers geometry and appearance reconstruction, enhancing understanding, planning, and decision-making in surgical scenes. Despite the impressive achievements of Neural Radiance Field (NeRF), its direct application to surgical scenes produces unsatisfying results due to two challenges: endoscopic sparse views and significant photometric inconsistencies.

MRI denoising with a non-blind deep complex-valued convolutional neural network.

MR images with high signal-to-noise ratio (SNR) provide more diagnostic information. Various methods for MRI denoising have been developed, but the majority of them operate on the magnitude image and neglect the phase information. Therefore, the goal of this work is to design and implement a complex-valued convolutional neural network (CNN) for MRI denoising.

Real-time control of distillation process to improve the recovery efficiency of ThF-LiCl-KCl molten salt.

The purification and recovery of chloride electrolyte molten salts are vital to reuse this valuable species and reduce the waste. Vacuum distillation method was used to investigate the recovery efficiency of LiCl-KCl mixed molten salt containing 20 wt% ThF. Rapid mass loss in the initial stage and the subsequent lower evaporation rate were significantly observed under 1173 K and 20 Pa due to the coordination species such as LiThF and LiThF.

Hospital utilization by older and younger patients in Canada: pre-pandemic findings.

Many countries are experiencing a post-pandemic surge in hospital utilization along with accelerating population aging. Maximal hospital efficiency is required, with utilization evidence essential for identifying appropriate hospital or broader health system reforms. We offer an investigation of the most recent pre-COVID year (2019-2020) of complete population-based hospital utilization data to describe and compare the use of hospitals by older (65+) and younger (0-64) people admitted for inpatient services in Canada.

Repeated lyophilization: A neo-method for urine-based reference materials preparation.

In urine drug testing, a cut-off value is often imposed to determine whether the sample is negative or positive. A matrix containing a reference substance helps counteract the adverse effects of the urine matrix across different laboratories to improve the consistency of final results. However, as a biological matrix, urine is prone to corruption and other problems that make it difficult to use as a reference sample.

IPNet: An Interpretable Network with Progressive Loss for Whole-stage Colorectal Disease Diagnosis.

Colorectal cancer plays a dominant role in cancer-related deaths, primarily due to the absence of obvious early-stage symptoms. Whole-stage colorectal disease diagnosis is crucial for assessing lesion evolution and determining treatment plans. However, locality difference and disease progression lead to intra-class disparities and inter-class similarities for colorectal lesion representation.