Inversion of interlayer scale using dynamic data of production wells in bottom water reservoirs: Sangtamu Oilfield, Tarim basin.

The target reservoir is a typical blocky bottom water reservoir. There are several interlayers of varying scales inside it, which impact the characteristics of the oil production and water breakthrough curves of the wells in the water flooding development oilfield, resulting in strong heterogeneity within the reservoir. The Sangtamu Oilfield has an average well spacing of approximately 600 m, causing a challenge in accurately identifying the range of small-scale interlayer spreading.

The role of GSK3β signaling mediated lysosomal biosynthesis dysregulation in fluoride-induced neurological impairment.

Neurological dysfunction induced by fluoride is still one of major concern worldwide, yet the underlying mechanisms remain elusive. To explore whether fluoride disrupts lysosomal biosynthesis via the GSK3β signaling, leading to neurological damage, both in vivo rat models and in vitro PC12 cell models were conducted. Subsequent findings revealed reduced spatial learning and memory abilities, decreased hippocampal neurons, and disrupted neuronal arrangement in NaF-treated rats.

Cardiac metabolic index as a predictor of new-onset diabetes in non-alcoholic fatty liver disease patients: a longitudinal cohort analysis.

Objective: The purpose of this investigation is to assess the clinical risk linked to the onset of diabetes in individuals with non-alcoholic fatty liver disease (NAFLD) through the utilization of the cardiac metabolic index (CMI), which is derived from triglycerides, high-density lipoprotein, height, and waist circumference. Research focusing on the application of CMI for evaluating diabetes risk among NAFLD patients remains scarce, and an exploration of the association between CMI and the emergence of diabetes within this demographic has not been conducted. This investigation aims to illuminate this connection, thereby providing novel insights into the prevention of diabetes progression in individuals with NAFLD.

Dual-driving of data and knowledge to reduce uncertainty in lithofacies interpolation.

The reservoir in focus has braided river delta front deposition, with multiple periods of submerged distributary channels within the reservoir. It also displays frequent cutting and stacking with local-connecting characteristics. Forecasting the sand distribution characteristics between wells in this type of reservoir brings a significant challenge for modeling.

Characterizing Genetic-Predisposed Proteins Involving Insomnia by Integrating Genome-Wide Association Study Summary Statistics.

Large case-control genome-wide association studies (GWASs) have detected loci associated with insomnia, but how these risk loci confer disease risk remains largely unknown. By integrating brain protein quantitative trait loci (pQTL) (N = 376, N = 152) and expression QTL (eQTL) (N = 452) datasets, with the latest insomnia GWAS summary statistics (N = 109,548, N = 277440), we conducted proteome/transcriptome-wide association study (PWAS/TWAS) and Mendelian randomization (MR) analysis, aiming to identify causal proteins involving in the pathogenesis of insomnia. We also explored the bi-directional causality between insomnia and several common diseases.

Effects of Different Microplastics on Wheat's ( L.) Growth Characteristics and Rhizosphere Soil Environment.

In order to reveal the effects of microplastics (MPs) on the growth and rhizosphere soil environmental effects of wheat ( L.), three microplastic types (polypropylene MPs (PP-MPs), high-density polyethylene MPs (HDPE-MPs), and polylactic acid MPs (PLA-MPs)), particle sizes (150, 1000, and 4000 μm), and concentrations (0.1, 0.

Design, Synthesis, and Bioactivity of Novel Coumarin-3-carboxylic Acid Derivatives Containing a Thioether Quinoline Moiety.

A series of coumarin-3-carboxylic acid derivatives containing a thioether quinoline moiety were designed and synthesized. The structures of these compounds were determined using H NMR, C NMR, and HRMS. The antibacterial activity of the compounds was evaluated against pv (), (), and ().

Caterpillar-Inspired Multi-Gait Generation Method for Series-Parallel Hybrid Segmented Robot.

The body structures and motion stability of worm-like and snake-like robots have garnered significant research interest. Recently, innovative serial-parallel hybrid segmented robots have emerged as a fundamental platform for a wide range of motion modes. To address the hyper-redundancy characteristics of these hybrid structures, we propose a novel caterpillar-inspired Stable Segment Update (SSU) gait generation approach, establishing a unified framework for multi-segment robot gait generation.

The Relationship Between Muscle Metabolic Index (Cr/CysC) Levels and Short-Term Prognosis with Acute Ischemic Stroke: Findings from a Cohort Study.

Objective: Sarcopenia significantly impacts prognosis in patients with acute ischemic stroke (AIS). This study investigates the relationship between serum creatinine/serum cystatin C (Cr/CysC) levels and short-term prognosis in AIS patients, aiming to inform post-treatment strategies.

Methods: We analyzed AIS patients at the First Affiliated Hospital of the University of Science and Technology of China from January 2022 to January 2024.

[A comparative study of dynamic versus static rehabilitation protocols after acute Achilles tendon rupture repair with channel assisted minimally invasive repair technique].

Objective: To explore the difference in effectiveness between a dynamic rehabilitation protocol and a traditional static rehabilitation protocol after the treatment of acute Achilles tendon rupture with channel assisted minimally invasive repair (CAMIR) technique through a prospective comparative trial, aiming to provide a reference for clinically selecting a feasible treatment regimen.

Methods: Patients with acute Achilles tendon rupture admitted between June 2021 and June 2022 were included in the study, with 60 patients meeting the selection criteria. They were randomly divided into a dynamic rehabilitation group ( =30) and a static rehabilitation group ( =30) using a computer-generated random number method.

Inhibition of CCR2 attenuates NLRP3-dependent pyroptosis after myocardial ischaemia-reperfusion in rats via the NF-kB pathway.

Myocardial infarction (MI) is a leading cause of mortality worldwide, contributing significantly to long-term cardiac dysfunction and heart failure. Effective therapeutic strategies are urgently needed to mitigate the extensive damage caused by MI and subsequent ischemia-reperfusion (I/R) injury. This study investigates the role of the Chemokine receptor 2 (CCR2) in regulating NLRP3-dependent cardiomyocyte pyroptosis following myocardial ischemia-reperfusion (MIR), elucidating its molecular mechanisms.

Experimental study on the motion characteristics and critical hydraulic parameters of microplastics in a freshwater environment.

The migration behavior of microplastics in water is affected by many factors; in particular, the migration mechanism of microplastics in the terrestrial freshwater environment is more complicated than that in the marine environment. In order to understand the migration behavior of microplastics in the freshwater environment, the hydraulic parameter thresholds of different types of microplastics in water were identified based on hydraulic experiments and force analysis methods. The results show that the motion state of microplastics is affected by their own internal factors and external environmental factors, and the flow rate is the key external factor affecting the change of their motion state.

How can traditional Chinese medicine enhance the efficacy of antibiotics in the treatment of MRSA-infected pneumonia: An experimental study on the combination of Reyanning mixture (RYN) and linezolid.

Ethnopharmacological Relevance: The Reyanning Mixture (RYN) is a Chinese patent medicine widely used in the treatment of respiratory inflammatory diseases in China and has potential in the treatment of bacteria-infected pneumonia.

Aim Of The Study: The present study aimed to demonstrate the therapeutic potential of RYN in combination with linezolid for the treatment of MRSA-infected pneumonia and to explore the mechanisms of action and active components.

Materials And Methods: The pharmacodynamics of RYN alone and in combination with linezolid was investigated in a rat model of MRSA-induced pneumonia.

Rapid capture of perfluorooctanoic acid and perfluorooctane sulfonate at environmentally relevant concentrations via the 'mesh trap' of triazine-based polymer network: Mechanism and photocatalytic regeneration.

Per- and polyfluoroalkyl substances (PFAS) pose a serious threat to groundwater (GW) environment worldwide due to their difficulty in removal and high toxicity. In this study, the 'mesh trap' of triazine-based polymerization network (SNW-1) demonstrated rapid capture performance for Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) at environmentally relevant concentrations (1 μg/L). The SNW-1 can remove more than 90 % of PFOA and PFOS within 300 s and still maintain superior performance under four common GW anions and different [pH] (3 - 10).

Phylogenetic analysis shows that (Pyrenulaceae) diversity is larger than expected: three new species and one new record discovered in China.

The lichenised fungal genus is a very common crustose lichen element in tropical to subtropical forests, but little research has been done on this genus in China. We carried out an integrative taxonomic study on in China using morphological, anatomical, chemical characters, and molecular data (ITS, nuLSU, mtSSU). Three new species with muriform ascospores containing red oil when over-mature were found: , and Molecular data and TLC results of and are for the first time reported and show that they are not synonyms.

Sysmex XN-9000 Hematology Analyzer Can Provide Reference for the Classification of Nucleated Cells in Body Fluid and Detect Malignant Serous Effusion.

Objective: The purpose of this study is to evaluate the accuracy of Sysmex XN-9000 hematology analyzer (XN-9000) in detecting nucleated cell classifications in serous effusion and to further evaluate whether it can be used for screening malignant serous effusion.

Methods: The consistency between XN-9000 and manual microscopy in the classification of nucleated cells was evaluated using Passing-Bablok regression and Bland-Altman plot. ROC analysis was applied to evaluate the value of HF-BF% in screening malignant specimens.

Clinical Characteristics, Species Distribution, and Drug Resistance of Non-Tuberculous Mycobacteria Lung Disease in Qingdao, China.

Objective: To analyze the clinical characteristics, species distribution and drug resistance of patients with non-tuberculous mycobacteria (NTM) lung disease in Qingdao, China.

Methods: Clinical data of patients with NTM lung disease and pulmonary tuberculosis (TB) treated at Qingdao Chest Hospital from July 2021 to July 2023 were retrospectively analyzed.

Results: The prevalence of NTM lung disease was 8.

Naringin alleviates fluoride-induced neurological impairment: A focus on the regulation of energy metabolism mediated by mitochondrial permeability transition pore.

The neurological impairment induced by fluoride is associated with mitochondrial dysfunction. Normal mitochondrial permeability transition pore (mPTP) opening plays a pivotal role in mitochondrial function. However, it remains unclear whether p53-dependent mPTP-related mitochondrial apoptosis is associated with fluoride-induced neurological impairment, and the alleviation of naringin on those.

Intercropping of tobacco and maize at seedling stage promotes crop growth through manipulating rhizosphere microenvironment.

Introduction: Changes in the rhizosphere microbiome and metabolites resulting from crop intercropping can significantly enhance crop growth. While there has been an increasing number of studies on various crop combinations, research on the intercropping of tobacco and maize at seedling stage remains limited.

Methods: This study is the first to explore rhizosphere effects of intercropping between tobacco and maize seedling stages, we analyzed the nitrogen, phosphorus and potassium nutrients in the soil, and revealed the important effects on soil microbial community composition and metabolite profiles, thereby regulating crop growth and improving soil balance.

[Auditory characteristics and disease progression trends of patients with common recessive deafness genes GJB2 and SLC26A4].

Patients who aged≥6 years and had hearing loss due to GJB2 or SLC26A4 mutation from the Chinese Deafness Genome Project between January 2020 and December 2023 were included. A total of 43 patients with GJB2 mutation were detected, including 25 males and 18 females, with a mean age of (20.4±11.

Refined egoist: The toxin-antitoxin immune system of T6SS.

The Type VI secretory system (T6SS) is a key regulatory network in the bacterial system, which plays an important role in host-pathogen interactions and maintains cell homeostasis by regulating the release of effector proteins in specific competition. T6SS causes cell lysis or competitive inhibition by delivering effector molecules, such as toxic proteins and nucleic acids, directly from donor bacterial cells to eukaryotic or prokaryotic targets. Additionally, it orchestrates synthesis of immune effectors that counteract toxins thus preventing self-intoxication or antagonistic actions by competing microbes.

Multi-Frequency Entropy for Quantifying Complex Dynamics and Its Application on EEG Data.

Multivariate entropy algorithms have proven effective in the complexity dynamic analysis of electroencephalography (EEG) signals, with researchers commonly configuring the variables as multi-channel time series. However, the complex quantification of brain dynamics from a multi-frequency perspective has not been extensively explored, despite existing evidence suggesting interactions among brain rhythms at different frequencies. In this study, we proposed a novel algorithm, termed multi-frequency entropy (mFreEn), enhancing the capabilities of existing multivariate entropy algorithms and facilitating the complexity study of interactions among brain rhythms of different frequency bands.