[Necessity and significance in basic and clinical research of liver xenotransplantation].

Liver transplantation is the only effective cure for end-stage liver disease. However,donor liver shortage has become a major problem,limiting the development of liver transplantation. Among the many ways to solve the problem of donor liver shortage,xenotransplantation has high feasibility and prospect of clinical application.

Development and evaluation of protective immunity of a ROP27 DNA vaccine against Eimeria tenella in chickens.

This study aimed to develop and evaluate the protective immunity of a ROP27 DNA vaccine against Eimeria tenella (E. tenella) in chickens. E.

Cost-effectiveness of angiographic quantitative flow ratio-guided coronary intervention: A multicenter, randomized, sham-controlled trial.

Background: The FAVOR (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients with Coronary Artery Disease) III China trial demonstrated that percutaneous coronary intervention (PCI) lesion selection using quantitative flow ratio (QFR) measurement, a novel angiography-based approach for estimating fractional flow reserve, improved two-year clinical outcomes compared with standard angiography guidance. This study aimed to assess the cost-effectiveness of QFR-guided PCI from the perspective of the current Chinese healthcare system.

Methods: This study is a pre-specified analysis of the FAVOR III China trial, which included 3825 patients randomized between December 25, 2018, and January 19, 2020, from 26 centers in China.

Low Density Lipoprotein Cholesterol but not Statins is the Direct Cause of Intracerebral Hemorrhage.

Objective: To investigate the direct and indirect relationships between statin use, low-density lipoprotein cholesterol (LDL-C) levels, and intracerebral hemorrhage (ICH), providing new insights into this complex scientific question.

Methods: In this cohort study, UK Biobank data from 2006-2010 were used to construct Structural Equation Models of statin use, LDL-C, and ICH, including 414,253 participants with LDL-C data. Published Genome-Wide Association Studies data were used for drug-target Mendelian Randomization analysis.

Functional Complete Revascularization as Determined by an Optimized Scoring System After Revascularization: A Post Hoc Analysis from Multi-Center PANDA III Trial.

Functional complete revascularization (CR) after percutaneous coronary intervention (PCI) as determined by classic residual functional SYNTAX score (c-rFSS) has been associated with improved prognosis. In this study, the c-rFSS algorithm is optimized for a novel modified rFSS (m-rFSS) and prognostic implications of this novel scoring is determined. The m-rFSS algorithm is updated for 2 clinical scenarios, i.

The impact of COVID-19 pandemic on sleep duration and mental health among middle school students: a 3-year cross-sectional survey.

Background: Since the outbreak of COVID-19 in late 2019, and until the Chinese government downgraded the pandemic control measures to Category B management in January 2023, various epidemic prevention measures were implemented across regions based on the local spread of the virus. Correspondingly, educational formats shifted between online and offline teaching according to the pandemic situation. Changes in daily life and teaching methods, along with the high initial mortality rate of COVID-19, have had varying degrees of negative impact on the mental health (MH) of adolescents.

The modified heart team protocol facilitated the revascularization decision-making quality in complex coronary artery disease.

Objectives: A lack of standardization in heart team implementation potentially leads to suboptimal decision-making quality, and we previously established a modified heart team protocol to improve the decision-making quality. The present trial was to validate the effect of the modified heart team implementation protocol on improving the decision-making quality versus the conventional protocol in complex coronary artery disease (CAD).

Methods: Eligible interventional cardiologists, cardiac surgeons and non-interventional cardiologists were randomly allocated to the intervention or control arm and established 12 heart teams in each arm.

Dual Thermally Activated Delayed Fluorescence from a Single Carbazole Derivative with Multiple Charge Transfer Pathways.

Two carbazole derivatives BPA-BNC and 4BPABNC are designed and synthesized to explore the probable dualemission behavior and mechanisms. BPA-BNC contains two arylamino donors and one B-N multi-resonance (MR) segment at 3,6,9-positions of a single carbazole, while 4BPABNC has two extraarylamine donors at 1,8-positions in addition to the above substituent groups. Two compounds in polar solvents show a clear dual emission peaked at near 490 and 540 nmwith high photoluminescence quantum yields of up to 98 %, short delayed lifetimesand extremely small single-triplet splitting energies.

Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases.

Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular death characterized by lipid peroxidation, is involved in the pathogenesis of diabetic cardiovascular diseases. The susceptibility to ferroptosis in diabetic hearts is possibly related to myocardial iron accumulation, abnormal lipid metabolism and excess oxidative stress under hyperglycemia conditions.

Ultrafast Laser Driven Ferromagnetic-Antiferromagnetic Skyrmion Switching in 2D Topological Magnet.

Light-spin coupling is an attractive phenomenon from the standpoints of fundamental physics and device applications, and has spurred rapid development recently. Whereas the current efforts are devoted to trivial magnetism, the interplay between light and nontrivial spin properties of topological magnetism is little known. Here, using first principles, rt-TDDFT and atomic spin simulations, the evolution of topological spin properties of monolayer CrInSe under laser is explored, establishing the ultrafast ferromagnetic-antiferromagnetic skyrmion reversal.

Clinical implication of NT-proBNP to predict mortality in patients with acute type A aortic dissection: a retrospective cohort study.

Objectives: Acute type A aortic dissection is a life-threatening cardiovascular disease commonly seen in emergency department, resulting in substantial mortality and morbidity. We aimed to investigate the prognostic value of N-terminal pro-B type natriuretic peptide (NT-proBNP) among this critically ill population.

Design: The design of this study was a retrospective cohort study.

Association of Liver Fibrosis Markers with Mortality Outcomes in Patients with Chronic Kidney Disease and Coronary Artery Disease: Insights from the NHANES 1999-2018 Data.

Introduction: The objective of this research was to explore the possible link between markers of liver fibrosis and survival rates in a group of adults who have been diagnosed with both chronic kidney disease (CKD) and coronary artery disease (CAD).

Methods: The National Health and Nutrition Examination Survey (NHANES) data (1999-2018) for participants with both CAD and CKD were analyzed. The fibrosis-4 index (FIB-4), Nonalcoholic Fatty Liver Score (NFS), Forns index, and aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio were identified as crucial biomarkers.

The Superiority of European Kidney Function Consortium Cystatin C-Based Formula for Risk Stratification of All-Cause and Cardiovascular Deaths in US Adults.

Introduction: We intended to compare the predictive value for all-cause and cardiovascular deaths between estimated glomerular filtration rate (eGFR) derived from the European Kidney Function Consortium (EKFC) cystatin C-based formula, the EKFC creatinine-based formula, and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) cystatin C- or creatinine-based formulas.

Methods: Overall, 4,132 participants from the National Health and Nutrition Examination Survey between 1999 and 2002 were included, and death information was obtained through the National Death Index. To compare predictive accuracy between EKFC eGFRcys (EKFC cystatin C-based formula), CKD-EPI eGFRcys (CKD-EPI cystatin C-based formula), EKFC eGFRcr (EKFC creatinine-based formula), and CKD-EPI eGFRcr (CKD-EPI creatinine-based formula), we conducted time-dependent receiver operator characteristic (ROC) curves and reclassification analysis.

The Impact of Adverse Childhood Experiences on the Development of Adolescent Risk-Taking: The Mediating Effect of Self-Control and Moderating Effect of Genetic Variations.

Risk-taking is a concerning yet prevalent issue during adolescence and can be life-threatening. Examining its etiological sources and evolving pathways helps inform strategies to mitigate adolescents' risk-taking behavior. Studies have found that unfavorable environmental factors, such as adverse childhood experiences (ACEs), are associated with momentary levels of risk-taking in adolescents, but little is known about whether ACEs shape the developmental trajectory of risk-taking.

Validation of the role of apolipoproteins in coronary artery disease patients with impaired kidney function for prognosis: a prospective cohort study in China.

Objective: This study aims to evaluate the relationship between apolipoproteins (ApoA1, ApoB, and the ApoB/A1 ratio) and the incidence of major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) and impaired kidney function, assessing their potential role in secondary prevention.

Method: A prospective cohort of 1,640 patients with impaired kidney function who underwent percutaneous coronary intervention in China was analyzed. Patients were categorized based on the measurements of ApoA1, ApoB, and ApoB/A1 ratio.

The association of the triglyceride-glucose index with the risk of atrial fibrillation: Analysis of the UK Biobank.

Background And Aims: The relationship between the triglyceride-glucose (TyG) index and the incidence of atrial fibrillation (AF) remains insufficiently explored. This investigation aims to elucidate the association between the TyG index and the long-term risk of developing AF.

Methods And Results: This cohort study analyzed data from 409,705 participants sourced from the UK Biobank database.

Optimal Definition and Risk Stratification in Prediabetes With Stable Coronary Heart Disease: A Prospective Cohort Study.

Background: The optimal definition and risk stratification approach to identify high-risk patients with prediabetes and stable coronary heart disease has not been well studied to date. The objective of the current study is to compare the prognostic value of different definitions of prediabetes, and to explore the role of "very-high-risk" (VHR) criteria according to the 2018 American Heart Association/American College of Cardiology cholesterol guideline in the risk stratification of patients with prediabetes and stable coronary heart disease.

Methods And Results: This prospective large-cohort study enrolled a total of 7930 patients with stable coronary heart disease.

Sleep quality and incident hypertension.

Introduction And Objectives: Poor sleep quality poses significant public health challenges worldwide. This study aimed to investigate the association between sleep quality and the risk of hypertension.

Methods: The study analyzed 284 250 adults from the UK Biobank (UKB) and 6104 participants from the English Longitudinal Study of Ageing (ELSA) without hypertension at baseline.

Exploring Shared and Unique Predictors of Positive and Negative Risk-Taking Behaviors Among Chinese Adolescents Through Machine-Learning Approaches: Discovering Gender and Age Variations.

Despite extensive research on the impact of individual and environmental factors on negative risk-taking behaviors, the understanding of these factors' influence on positive risk-taking, and how it compares to negative risk taking, remains limited. This research employed machine-learning techniques to identify shared and unique predictors across individual, family, and peer domains. Participants (N = 1012; 44% girls; Mage = 14.

The Predictive and Prognostic Value of the Systemic Immune-Inflammation Index for Congestive Heart Failure.

Background: The systemic immune-inflammatory index (SII), calculated by (platelet count × neutrophil count)/lymphocyte count, is a novel biomarker with predive and prognostic value in numerous diseases. However, the relationship between SII and congestive heart failure (CHF) is not clear. This study aims to document the association of SII with the prevalence of CHF in the whole population and the long-term prognosis in CHF patients.

The Longitudinal Association Between Negative Life Events and Problematic Social Media Use Among Chinese College Students: The Mediating Role of FoMO and the Moderating Role of Positive Parenting.

Negative life events are one of the risk factors leading to problematic social media use (PSMU) among Chinese college students, but the underlying mechanism between them remains unclear. Based on compensatory internet use theory, a moderated mediation model was examined, with two dimensions of fear of missing out (FoMO) considered as parallel mediators and positive parenting as a moderator. A total of 525 college students (57.

A Tandem-Locked Fluorescent Probe Activated by Hypoxia and a Viscous Environment for Precise Intraoperative Imaging of Tumor and Instant Assessment of Ferroptosis-Mediated Therapy.

Noninvasive fluorescence detection of tumor-associated biomarker dynamics provides immediate insights into tumor biology, which are essential for assessing the efficacy of therapeutic interventions, adapting treatment strategies, and achieving personalized diagnosis and therapy evaluation. However, due to the absence of a single biomarker that effectively reflects tumor development and progression, the currently available optical diagnostic agents that rely on "always-on" or single pathological activation frequently show nonspecific fluorescence responses and limited tumor accumulation, which inevitably compromises the accuracy and reliability of tumor imaging. Herein, based on intramolecular charge transfer (ICT) and twisted intramolecular charge-transfer (TICT) hybrid mechanisms, we report a tandem-locked probe, , for simultaneously specific imaging-guided tumor resection and ferroptosis-mediated tumor ablation evaluation under the coactivation of nitro reductase (NTR)/viscosity.

Subclinical hypothyroidism as an independent predictor of cardiovascular prognosis in left ventricular thrombus patients.

Objectives: Left ventricular thrombus (LVT) is associated with an increased risk of adverse cardiovascular events, and thyroid hormones are known to affect the cardiovascular system in various ways. However, subclinical thyroid dysfunction still deserves to be emphasized, and its impact on the prognosis of patients with LVT is rare but needs to be investigated.

Methods: We used retrospective data from patients diagnosed with LVT at Fuwai Hospital over the past 10 years to assess the relationship between thyroid functional status and prognosis of LVT using multivariate Cox proportional hazards models, and validated the improved predictive effect of including thyroid function in the prognostic assessment of LVT using receiver operating characteristic (ROC) curves.

Metabolic Acidity/HO Dual-Cascade-Activatable Molecular Imaging Platform Toward Metastatic Breast Tumor Malignancy.

Fluorescence imaging in the second near-infrared window (NIR-II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR-II probes are limited by either being "always on" or responding to one stimulus, leading to low signal-to-noise ratios and potential false positives. We introduced a dual-lock-controlled probe, HN-PBA, activated by both HO and tumor acidic environment.

Dual-Response Functionalized Mitochondrial Fluorescent Probe for a Double Whammy Monitoring of Hypochlorite and Sulfur Dioxide in Heat Shock via Time Scales.

Heat shock seriously affects the normal functioning of an organism and can lead to damage and even death in severe cases. To prevent or treat heat shock-related diseases, we require a better understanding of the mechanism of thermocytotoxicity. Here, we designed a functionalized dual-response fluorescent probe () that could individually or simultaneously detect hypochlorous acid (HClO) and sulfur dioxide (SO) without interfering with each other and achieved the simultaneous tracing of both during the heat shock process for the first time.