Publications by authors named "Dou Dou Chen"
This study reports sequential dehydrogenation and transfer oxygenation of 1,2-diarylepoxides by high-valent phenCu(III)(CF) and DMSO to produce 1,2-diketones. The Cu(III)-CF compound serves as a CF radical source to abstract the hydrogen atom of the epoxide ring. The resulting ether α-carbon radical undergoes ring-opening rearrangement to give a ketone α-carbon radical intermediate, which is oxygenated by DMSO with the release of MeS.
View Article and Find Full Text PDFIn order to improve the degradation activity of β-glucosidase (CpBgl) from Coniophora puteana, the structural modification was conducted. The enzyme activity of mutants CpBgl-Q20C and CpBgl-A240S was increased by 65.75% and 58.
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- The study aimed to assess the effectiveness of pupilloplasty combined with phacoemulsification and intraocular lens implantation (PPI) in treating cataracts caused by uveitis in 28 patients.
- Results showed that most patients achieved improved vision and normal intraocular pressure post-surgery, with a low complication rate and a 96.43% success rate in preventing uveitis recurrence during long-term follow-ups.
- Histopathological analysis of iris tissues revealed changes such as stroma atrophy and pigment cell hyperplasia, indicating ongoing inflammation even in quiescent uveitis cases.
Background: We aimed to study seizure characteristics during the acute phase of Japanese encephalitis (JE) in children, determine the risk factors of postencephalitic epilepsy (PEE), establish a risk prediction model for the disease, and construct a nomogram to visualize the model.
Methods: We retrospectively analyzed the clinical data and follow-up results of 328 children with JE who were hospitalized between January 2011 and December 2020. Risk factors were screened using univariable analysis, a predictive model was built using binary logistic analysis, lasso regression was used for variable screening, and a nomogram was developed.
Objective: We aimed to develop a predictive nomogram for the early detection of hydrocephalus in children with bacterial meningitis.
Methods: This retrospective study was based on data of children with bacterial meningitis admitted to our hospital between January 2016 and December 2020. Risk factors were evaluated using univariate analysis, and the predictive model/nomogram was built using binary logistic analysis.
Article Synopsis
- A three-generation Chinese family with a history of autosomal dominant congenital nuclear cataract was studied to identify the gene responsible for the condition.
- The researchers found a specific mutation (p.R76H) in the Cx50 gene that was linked to the cataract phenotype, which was not present in a control group.
- Although the mutation did not affect protein solubility or apoptosis rates in a cell model, it did impair the formation of gap junctions, contributing to lens opacity.
Background: One prominent pathological feature of congenital aniridia is hypoplasia of the iris, often accompanied by other eye abnormalities. The objective of this study is to identify gene mutations responsible for autosomal dominance in a Chinese family with congenital aniridia, progressive cataracts and mental retardation.
Methods: A total of 11 family members, including 6 affected and 5 unaffected individuals were recruited.
Long noncoding RNAs (lncRNA) have been recognized as significant regulators in the progression of atherosclerosis (AS). Oxidized low-density lipoprotein (ox-LDL) can induce macrophage inflammation and oxidative stress, that serves important roles in AS. However, the exact function of lncRNA NEAT1 and its possible molecular mechanism in AS remain unclear.
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- The study aimed to find the mutation spectrum of the CRYBA1/A3 gene and its correlation to congenital cataract in Chinese families.
- Out of 47 families studied, nuclear cataract was most prevalent, and a specific CRYBA1/A3 deletion mutation (ΔG91) was found in 6.4% of families with nonprogressive cases.
- The ΔG91 mutation appears to occur independently across families, suggesting it may be a common, significant mutation related to nonprogressive nuclear cataracts.