The Optiflow™ interface for chronic CPAP in infants.

Continuous positive airway pressure (CPAP) is increasingly used in infants. However, the limited number of commercially masks available for infants is challenging. The use of the Optiflow™ nasal cannula (Fisher & Paykel) with a regular CPAP device has been recently reported for chronic CPAP in children, with an objective improvement in polysomnographic events.

Why NIV setting definitions may be tricky: Trigger sensitivity.

Noninvasive ventilation (NIV) is widely used in children. The spontaneous/timed (S/T) mode is the most common used mode for home NIV. Different devices are available, and the manufacturers are free to name the modes and define the settings, with no regulation.

Atorvastatin and telmisartan do not reduce nasopharyngeal carriage of SARS-CoV-2 in mild or moderate COVID-19 in a phase IIb randomized controlled trial.

Observational studies suggest a reduction in fatal or severe COVID-19 disease with the use of ACE2 inhibitors and statins. We implemented a randomized controlled tree-arm open label trial evaluating the benefits of adding telmisartan (TLM) or atorvastatin (ATV) to lopinavir boosted ritonavir (LPVr) on the SARS-CoV-2 nasopharyngeal viral load in patients with mild / moderate COVID-19 infection in Côte d'Ivoire. RT-PCR positive COVID-19 patients ≥ 18 years, with general or respiratory symptoms for less than 7 days were randomized (1:1:1) to receive LPVr (400 mg/100 mg twice daily), LPVr + TLM (10 mg once daily) or LPVr + ATV (20 mg once daily) for 10 days.

Seroprevalence of SARS-CoV-2 antibodies and retrospective mortality in two African settings: Lubumbashi, Democratic Republic of the Congo and Abidjan, Côte d'Ivoire.

Although seroprevalence studies have demonstrated the wide circulation of SARS-COV-2 in African countries, the impact on population health in these settings is still poorly understood. Using representative samples of the general population, we evaluated retrospective mortality and seroprevalence of anti-SARS-CoV-2 antibodies in Lubumbashi and Abidjan. The studies included retrospective mortality surveys and nested anti-SARS-CoV-2 antibody prevalence surveys.

Floristic Diversity as an Indicator in Low and High Endemic Buruli Ulcer Areas in Côte d'Ivoire.

Unlabelled: is an environmental bacterium responsible for Buruli ulcer. This disease has a high frequency index in humid tropical regions, with a high incidence in Sub-Saharan Africa. The ecology and mode of transmission of this disease is not well established.

Towards regional scientific integration in Africa? Evidence from co-publications.

Regional scientific integration is a critical pathway for the development of an integrated African research area and knowledge-based society. On the African continent, progress in scientific production and integration has remained limited, mostly led by a global or international agenda, and bound to a few top publishing nations. The high-level policy commitments and the accumulated policies and strategies developed and pursued under the various intertwined sub-regional economic groupings have, to date, only diversely contributed to policy alignment and coordination in the area of science, technology, and innovation (STI) across Africa.

Investigation of Phages Infecting Strains B and C, and in Sewage and Ebrié Lagoon, Côte d'Ivoire.

Bacteriophages are a promising biotechnological against bacterial pathogens. Currently, phage research is garnering interest in sub-Saharan countries as bacterial resistance to antibiotics becomes widespread. They are sought in all environments as they offer the possibility of a sustainable alternative to antibiotics.

Mosquito (Diptera: Culicidae) Larval Ecology in Rubber Plantations and Rural Villages in Dabou (Côte d'Ivoire).

In Côte d'Ivoire, rubber cultivation has more than doubled since 2010. These mass agricultural areas require a large workforce with little information on how this environment might impact risk of mosquito-borne diseases. The objective of this study was to assess the larval ecology of mosquitoes in rubber areas of Dabou, Côte d'Ivoire.

Impacts of nutrient loading and fish grazing on the phytoplankton community and cyanotoxin production in a shallow tropical lake: Results from mesocosm experiments.

Given the increasing eutrophication of water bodies in Africa due to increasing anthropogenic pressures, data are needed to better understand the responses of phytoplankton communities to these changes in tropical lakes. These ecosystems are used by local human populations for multiple purposes, including fish and drinking water production, potentially exposing these populations to health threats if, for example, an increase in toxic cyanobacterial blooms is associated with increasing eutrophication. To test the short-term response of the phytoplankton community to the addition of nutrients (phosphorus and nitrogen, alone or in combination) and Nile tilapia, we developed an in situ mesocosm experiment in a freshwater lagoon located near Abidjan (Ivory Coast).

Team experience of nasopharyngeal samples reception, decontamination, and sorting during the COVID-19 pandemic (2020) at Institut Pasteur Côte d'Ivoire.

Molecular testing sensitivity, which allows for early diagnosis of the 2019 coronavirus disease (COVID-19), could be affected by sample quality, storage, and transportation timeframe to the laboratory, along with bias related to the pre-analytic phase. The present study reports the selection and decontamination of nasopharyngeal samples during COVID-19 management at the Institut Pasteur Côte d'Ivoire. The objective of this work was to organize sample reception management and report a complete picture of sample selection and decontamination in the context of diagnosis activity decentralization.

Viral and bacterial factors of mother-to-child transmission of hepatitis B virus.

Hepatitis B virus (HBV) infection is the tenth leading cause of death worldwide. Mother-to-child transmission of HBV occurring mainly at delivery remains one of the most common routes of infection in developing countries. One of the main challenges concerning HBV in Africa is to implement a prevention policy aiming at interrupting the cycle of pseudo-vertical transmission of this infection.

Artemisinin-Based Combination Therapy Synergized with Medicinal Plants to Induce Musculotoxic Effects.

Introduction: Multivisceral, neurological, hepatic, and renal damage has been witnessed following the use of artemisinin-based combination therapy (ACT) and herbal medicine. These multiple organ damages make us think of muscle damage. The objective was to study the myotoxicity of the combination of ACTs with medicinal plants.

Geographical Distribution of Ticks Ixodidae in Côte d'Ivoire: Potential Reservoir of the Crimean-Congo Hemorrhagic Fever Virus.

Ticks and tick-borne diseases are a major issue. These recent years, tick-borne diseases have attracted much attention because of their increasing incidence and the significant damage that they cause to livestock and human health. The objective was to identify the different species of ticks found in cattle and to determine the prevalence of Crimean-Congo hemorrhagic fever virus (CCHFV) in these different areas.

Estimates of serious fungal infection burden in Côte d'Ivoire and country health profile.

Due to limited access to more powerful diagnostic tools, there are few data on the burden of fungal infections in Côte d'Ivoire, despite a high HIV and TB burden and many cutaneous diseases. Here we estimate the burden of serious fungal infections in this sub-Saharan country with a health profiling description. National demographics were used and PubMed searches to retrieve all published articles on fungal infections in Côte d'Ivoire and other bordering countries in West Africa.

Antimicrobial resistance and virulence associated genes in Campylobacter jejuni isolated from chicken in Côte d'Ivoire.

Introduction: Campylobacter jejuni is one of the major causes of gastroenteritis worldwide of the last century. The aim of this study was to investigate the antibiotics profiles and the virulence gene in C. jejuni strains isolated from chicken in Côte d'Ivoire.