Publications by authors named "Dorte Terp Andersen"
Article Synopsis
- The study aimed to evaluate the relationship between tacrolimus concentrations in whole blood and peripheral blood mononuclear cells (PBMCs) in kidney transplant patients, ultimately to improve therapeutic drug monitoring.
- Researchers collected pharmacokinetic data from 63 patients, analyzing drug concentrations using advanced techniques and considering patient genetic factors.
- Results indicated that while a model could describe whole blood concentrations effectively, predicting PBMC concentrations from whole blood was challenging due to unexplained variability, suggesting direct measurement of PBMC concentrations may be necessary for future research.
Introduction: Congenital fibrinogen disorders are a heterogenous group of fibrinogen defects.
Case Presentation: Here, we describe hypodysfibrinogenemia in a 33-year-old female patient with provoked recurrent deep vein thrombosis (DVT) diagnosed based on decreased functional and antigenic fibrinogen levels with a decreased functional/antigenic fibrinogen ratio. Definitive diagnosis of congenital hypodysfibrinogenemia is done by genotyping using whole-exome sequencing, which identified the γ326Cys→Tyr mutation combined with single-nucleotide polymorphisms: rs2070011 and rs2070018 in FGA and rs1049636 in FGG.
This study aims to determine the prevalence and clinical significance of anti-CCP isotype IgA in a population of patients with primary Sjögren's syndrome (pSS). Sixty-two patients diagnosed according to the USA-European classification criteria for pSS were examined two to four times during a 60.4-month follow-up, and clinical and laboratory data were registered prospectively.
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