Publications by authors named "Dorsa Yahya Rayat"
PathBank (https://pathbank.org) and its predecessor database, the Small Molecule Pathway Database (SMPDB), have been providing comprehensive metabolite pathway information for the metabolomics community since 2010. Over the past 14 years, these pathway databases have grown and evolved significantly to meet the needs of the metabolomics community and respond to continuing changes in computing technology.
View Article and Find Full Text PDFArticle Synopsis
- DrugBank, launched in 2006, is a leading resource for drug and pharmaceutical information, receiving over 30 million views annually.
- The recent update, DrugBank 6.0, has significantly expanded its database, increasing the number of FDA approved drugs by 72% and investigational drugs by 38%.
- Enhancements include thousands of new pathways for drug mechanisms, improved datasets for 11,891 drugs, and added experimental data like MS/MS spectra for nearly 9,500 small molecule drugs, making it more valuable for researchers across multiple fields.
α-synuclein interaction with zero-valent iron nanoparticles accelerates structural rearrangement into amyloid-susceptible structure with increased cytotoxic tendency.
Int J Nanomedicine
October 2019
Aim: It has been indicated that NPs may change the amyloidogenic steps of proteins and relevant cytotoxicity. Therefore, this report assigned to explore the impact of ZVFe NPs on the amyloidogenicity and cytotoxicity of α-synuclein as one of the many known amyloid proteins.
Methods: The characterization of α-synuclein at amyloidogenic condition either alone or with ZVFe NPs was carried out by fluorescence, CD, UV-visible spectroscopic methods, TEM study, docking, and molecular modeling.