Publications by authors named "Dorsa Majdpour"
Article Synopsis
- A study was conducted to evaluate a fully automated insulin delivery system (using faster-acting insulin aspart and pramlintide) for people with type 1 diabetes that does not require meal input, compared to a system that requires precise carbohydrate counting.
- The trial involved 28 adults with type 1 diabetes, with 24 completing both intervention systems to determine which maintained glucose levels more effectively.
- Results indicated that the fully closed-loop system maintained glucose levels within the target range 74.3% of the time, while the hybrid system achieved 78.1%, showing that the new system was non-inferior despite slightly lower effectiveness.
Objectives: A fully automated insulin-pramlintide-glucagon artificial pancreas that alleviates the burden of carbohydrate counting without degrading glycemic control was iteratively enhanced until convergence through pilot experiments on adults with type 1 diabetes.
Methods: Nine participants (age, 37±13 years; glycated hemoglobin, 7.7±0.
Rtf1 is a conserved RNA polymerase II (RNAPII) elongation factor that promotes cotranscriptional histone modification, RNAPII transcript elongation, and mRNA processing. Rtf1 function requires the phosphorylation of Spt5, an essential RNAPII processivity factor. Spt5 is phosphorylated within its C-terminal domain (CTD) by cyclin-dependent kinase 9 (Cdk9), the catalytic component of positive transcription elongation factor b (P-TEFb).
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