Publications by authors named "Dorra Bouazzi"
Background: Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, recurrent, and inflammatory disease. HS is fairly rare among the population. This study was a part of the Global Hidradenitis Suppurativa Atlas (GHiSA) initiative, aiming to establish the prevalence of HS, based on a questionnaire and subsequent clinical examination targeting healthy adults accompanying patients undergoing care in a tertiary hospital.
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- This study focuses on hidradenitis suppurativa (HS) in Algeria, a condition that has been mostly studied in Western populations with little research in Africa or Asia.
- A survey including 1434 participants found an HS prevalence of 0.78% in the Algerian adult population, which is similar to rates observed in Australia and Europe.
- The study confirmed that the GHiSA questionnaire used for screening HS is both reliable and valid, with high sensitivity and specificity in identifying cases.
Article Synopsis
- The global burden of hidradenitis suppurativa (HS) is poorly understood due to limited and varying prevalence data, which has been affected by different methodologies and diagnostic approaches.
- The Global Hidradenitis Suppurativa Atlas (GHiSA) aims to accurately determine HS prevalence by using a validated questionnaire for screening, followed by physician validation for positive cases, assessing about 10% of negatives for diagnostic accuracy.
- Currently, GHiSA is conducting prevalence studies in 58 countries to create a comprehensive global prevalence estimate through proportional meta-analysis, allowing for direct international comparisons that were not previously feasible.
Article Synopsis
- - Acne fulminans (AF) is a serious and rare skin condition that can cause significant scarring, and standard treatments are often insufficient, leading to a need for better therapies.
- - A study reviewed 3 clinical cases and 12 cases from the literature where TNF-α inhibitors, particularly adalimumab, were used to treat AF, showing clinical improvement in a majority of patients after 1 to 7 months.
- - While the treatment showed promising results with mild and reversible side effects, more research, including randomized controlled trials, is necessary to determine effective dosages and timing for TNF-α inhibitors in AF management.
Hidradenitis suppurativa (HS) is a chronic skin disease that significantly impairs the quality of life of affected individuals. The disease is characterized by persistent purulent lesions in specific anatomical areas, and its pathophysiology involves multiple factors, including inflammation, genetics, the microbiome, and environmental components. Recent research suggests a potential role for pathogenic bacteria in HS, highlighting the importance of the communication between the human host and the microbiome in maintaining homeostasis and immune system reactivity.
View Article and Find Full Text PDFBackground: Epidemiologic hidradenitis suppurativa (HS) studies from Africa are lacking. This study aimed at uncovering the prevalence of HS in Lagos, Nigeria, to validate an HS screening questionnaire, and to contribute to the Global Hidradenitis Suppurativa Atlas (GHiSA).
Methods: This was a cross-sectional study of 802 healthy adults accompanying their relations to the outpatient clinic of Family Medicine and Ophthalmology at the Lagos State University Teaching Hospital in Lagos, Nigeria, following ethical approval.
Common skin disorders such as acne vulgaris, rosacea and folliculitis are bothersome prevalent inflammatory diseases of hair follicles that can easily be investigated bedside using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) with micrometre resolution, opening a novel era for high-resolution hair follicle diagnostics and quantitative treatment evaluation. EMBASE, PubMed and Web of Science were searched until 5 January 2023 to identify all studies imaging hair follicle characteristics by RCM and OCT for diagnosis and monitoring of treatment in hair follicle-based skin disorders. This study followed PRISMA guidelines.
View Article and Find Full Text PDFBackground: Acne in adolescence and adulthood is believed to have a long-term impact on socioeconomic status (SES) and health-related quality-of-life (HRQoL) in adults.
Objective: To estimate the cross-sectional prevalence of medically treated (MedTreAc) and untreated acne (UnTreAc) and to characterize its long-term impact in adults.
Methods: A nationwide cross-sectional study on 17 428 blood donors aged 18-35 was performed.
Hyperhidrosis is a dermatosis presenting as pathologically excessive focal or generalized sweating. The stigmatizing nature of hyperhidrosis may cause patients to feel embarrassment and apprehension about their symptoms and experience a significant decrease in well-being. Severe cases of hyperhidrosis can also increase the risk of developing psychiatric and somatic comorbidities.
View Article and Find Full Text PDFBackground: Adalimumab, a tumor necrosis factor-α inhibitor, is a biologic used for the treatment of moderate-to-severe hidradenitis suppurativa (HS). It is well known that patients may experience loss of efficacy from its use in other conditions, and it is suggested that developing a strategy for therapeutic drug monitoring (TDM) may help secure optimal clinical outcomes.
Objectives: We sought to determine serum adalimumab concentrations and anti-adalimumab antibody (AAA) status in patients with moderate-to-severe HS.
Background And Objectives: To investigate whether optical coherence tomography (OCT) could be utilized to characterize blood flow and vessel dimensions of facial telangiectasias before and during consecutive intense pulsed light (IPL) treatment.
Study Design/materials And Methods: Dynamic OCT (D-OCT) was used to image telangiectasia immediately before and after, 1-3 days after, and 1 month after IPL treatment. Measurements included vessel width and depth, blood flow, and attenuation.
Article Synopsis
- * Common issues among these patients included obesity (median BMI percentile 88), with comorbidities like acne (32.8%), hirsutism (19.3%), and pilonidal cysts (16.4%).
- * Treatment options included topical applications like resorcinol and clindamycin, oral medications (tetracycline and clindamycin with rifampicin), and surgical interventions;
Background: The possible connection between hidradenitis suppurativa (HS) patients undergoing surgery and higher complications/recurrences has been implied, but inconsistent results reported.
Objective: To assess the complication and recurrence rates for HS patients undergoing surgery and to evaluate whether known HS comorbidities and habits (smoking, obesity and diabetes) have an effect on the complication and recurrence rates.
Materials And Methods: A systematic review was conducted by 2 reviewers.
We report a case of invasive dermatophytosis mimicking vasculitis. A patient consulted the Department of Dermatology, Zealand University Hospital, Roskilde, Denmark for the assessment of violaceous/erythematous lesions thought to be vasculitis. She had prior to this been treated with the immunosuppressive drug teriflunomid.
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