Generation of a monoclonal antibody to a cryptic site common to both integrin beta1 as well as gelatinase MMP9.

Integrins are one class of cell surface receptors that have been implicated in the regulation of a diverse set of cellular processes, including cell adhesion, migration, and invasion as well as gene expression, differentiation, and signal transduction. Cellular invasion not only requires the adhesive properties of integrins but also the proteolytic properties of matrix-degrading enzymes, such as the metalloproteinases (MMPs). Previous studies have shown that integrin alphavbeta3 is a receptor for MMP2, localizing its proteinase activity to the cell surface, ultimately leading to site-specific extracellular matrix (ECM) degradation.

Beyond stereotypes: promoting safer sex behaviors among Latino adolescents.

Latino youth are at increasing risk for consequences of risky sexual behavior including pregnancy and sexually transmitted diseases, as well as HIV infection. The diversity among Latinos and the prevalence of stereotypes about Latino sexual altitudes, beliefs, and behaviors present barriers in effective prevention and treatment. Strategies for promoting safe sex among Latino adolescents include recognizing the diversity among Latino adolescents and assessing attitudes, beliefs, and values that can be used to support safer sex behaviors.