Publications by authors named "Dorothy M Chen"
Article Synopsis
- The study investigates the genetic factors influencing levels of prostate-specific antigen (PSA), which could enhance its effectiveness for prostate cancer screening among men.
- Researchers conducted a transcriptome-wide association study (TWAS) using data from nearly 100,000 prostate cancer-free men, identifying 173 unique genes associated with PSA levels, with 151 resembling findings in another large dataset.
- Further analysis revealed 20 genes that influenced PSA levels independently from identified genetic variants, with several showing a potential causal relationship and the need for additional research to understand these genetic influences better.
Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility to screen for prostate cancer (PCa). We thus conducted a transcriptome-wide association study (TWAS) of PSA levels using genome-wide summary statistics from 95,768 PCa-free men, the MetaXcan framework, and gene prediction models trained in Genotype-Tissue Expression (GTEx) project data. Tissue-specific analyses identified 41 statistically significant (p < 0.
View Article and Find Full Text PDFStudy Objectives: Disrupted daily rhythms are associated with mild cognitive impairment (MCI) and dementia. The specific nature of how rhythms and cognition are related, however, is unknown. We hypothesized characteristics from a nonparametric estimate of circadian rest-activity rhythm patterns would be associated to the development of MCI or dementia.
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