Viability and function of 8-day-stored apheresis platelets.

Background: Methods of bacterial detection and pathogen inactivation of platelets (PLTs) may allow extended storage of PLTs as long as PLT quality is maintained.

Study Design And Methods: Twenty normal volunteers had their PLTs collected with an apheresis machine (Haemonetics Corp.).

Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival.

Background: Determining reversible aspects of the platelet storage lesion may result in improved function and survival of transfused platelets.

Study Design And Methods: Using a model of high-dose (apheresis-derived) platelet concentrates (PC), functional changes imposed by transient adverse metabolic conditions (pH < 6.0 for 1-2 hr) that could be reversed by autologous plasma rescue followed by standard platelet storage were investigated.