Protection mediated by chemokine CXCL10 in BALB/c mice infected by Leishmania infantum.

Background: Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response. Chemokines have a direct involvement in the pathogenesis of leishmaniasis, causing a rapid change in the expression of these molecules during infection by Leishmania.

Objectives: Herein, it was investigated the role of CXCL10 in controlling infection by L.